open access

Vol 50, No 6 (2016)
Original research articles
Submitted: 2016-02-25
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The relationship between serum paraoxonase levels and carotid atherosclerotic plaque formation in Alzheimer's patients

Ayşe Arslan, Fatma Aykan Tüzün, Harun Arslan, Halit Demir, Sibel Tamer, Canan Demir, Muhterem Tasin
DOI: 10.1016/j.pjnns.2016.07.002
·
Neurol Neurochir Pol 2016;50(6):403-409.

open access

Vol 50, No 6 (2016)
Original research articles
Submitted: 2016-02-25

Abstract

Low paraoxonase 1 (PON1) activity and carotid atherosclerosis have been suggested to be important risk factors for dementia. However, the studies to date could not fully clarify the relationship between PON1, carotid atherosclerosis and dementia. The present study aimed to measure carotid atherosclerosis and PON1 activity in Alzheimer's Disease and to evaluate the relationship between them. The study included 25 Alzheimer's patients and 25 control subjects, for a total of 50 individuals. The study measured the serum PON1 activity and other biochemical parameters and carotid atherosclerotic plaque values of the participants. The mean paraoxonase activity (31.06±2.31U/L) was significantly lower in the Alzheimer's group compared to the control group (59.05±7.05U/L) (P<0.001). Nonetheless, the carotid plaque values were significantly higher in the patient group (3.02±0.52mm) compared to the control group (1.84±0.45mm) (P<0.001). Furthermore, there was a negative correlation (81.0%) between PON1 activity and carotid plaque in the overall study group (P<0.05). Also serum homocystein level was higher in the patient group (22.15±7.05) compared to the control group (13.30±3.32). In conclusion, our findings show inverse association between PON1 activity and carotid atherosclerosis in Alzheimer patients: the lower the PON1 activity the more progressed the atherosclerotic process in AD.

Abstract

Low paraoxonase 1 (PON1) activity and carotid atherosclerosis have been suggested to be important risk factors for dementia. However, the studies to date could not fully clarify the relationship between PON1, carotid atherosclerosis and dementia. The present study aimed to measure carotid atherosclerosis and PON1 activity in Alzheimer's Disease and to evaluate the relationship between them. The study included 25 Alzheimer's patients and 25 control subjects, for a total of 50 individuals. The study measured the serum PON1 activity and other biochemical parameters and carotid atherosclerotic plaque values of the participants. The mean paraoxonase activity (31.06±2.31U/L) was significantly lower in the Alzheimer's group compared to the control group (59.05±7.05U/L) (P<0.001). Nonetheless, the carotid plaque values were significantly higher in the patient group (3.02±0.52mm) compared to the control group (1.84±0.45mm) (P<0.001). Furthermore, there was a negative correlation (81.0%) between PON1 activity and carotid plaque in the overall study group (P<0.05). Also serum homocystein level was higher in the patient group (22.15±7.05) compared to the control group (13.30±3.32). In conclusion, our findings show inverse association between PON1 activity and carotid atherosclerosis in Alzheimer patients: the lower the PON1 activity the more progressed the atherosclerotic process in AD.

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Keywords

Alzheimer' s disease, PON1, Homocystein, Carotid atherosclerosis

About this article
Title

The relationship between serum paraoxonase levels and carotid atherosclerotic plaque formation in Alzheimer's patients

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 50, No 6 (2016)

Pages

403-409

DOI

10.1016/j.pjnns.2016.07.002

Bibliographic record

Neurol Neurochir Pol 2016;50(6):403-409.

Keywords

Alzheimer's disease
PON1
Homocystein
Carotid atherosclerosis

Authors

Ayşe Arslan
Fatma Aykan Tüzün
Harun Arslan
Halit Demir
Sibel Tamer
Canan Demir
Muhterem Tasin

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