open access

Vol 50, No 5 (2016)
Original research articles
Submitted: 2016-02-15
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Hemostasis vs. epidural fibrosis?: A comparative study on an experimental rat model of laminectomy

Hakan Erdogan, Bilal Kelten, Matem Tuncdemir, Salime Pelin Erturkuner, Hafize Uzun, Alper Karaoglan
DOI: 10.1016/j.pjnns.2016.05.002
·
Neurol Neurochir Pol 2016;50(5):323-330.

open access

Vol 50, No 5 (2016)
Original research articles
Submitted: 2016-02-15

Abstract

Aim

The aim of this study was to evaluate the histopathological and biochemical impact and effectiveness of two hemostatic agents, Ankaferd blood stopper (ABS) and Microporous Polysaccharide Hemospheres (MPH), on epidural fibrosis in an experimental rat laminectomy model.

Material and methods

Twenty adult Wistar albino rats were divided into MPH-treated (n=6), ABS-treated (n=6) and control (n=8) groups. Laminectomy of the lumbar spine was performed in all animals and treatment groups were exposed to MPH and ABS while closure was applied in control group as per usual. Epidural fibrosis was evaluated in all groups macroscopically, histopathologically, biochemically and with electron microscopy four weeks later.

Results

Statistically, it was found that MPH-treated group had significantly less epidural fibrosis compared to ABS-treated and control groups.

Conclusion

We compared two hemostatic agents for their propensity to cause adhesions in the present study. Our results show that MPH significantly reduces epidural scar formation and dural adhesion in a rat model of laminectomy while ABS increases postoperative fibrosis.

Abstract

Aim

The aim of this study was to evaluate the histopathological and biochemical impact and effectiveness of two hemostatic agents, Ankaferd blood stopper (ABS) and Microporous Polysaccharide Hemospheres (MPH), on epidural fibrosis in an experimental rat laminectomy model.

Material and methods

Twenty adult Wistar albino rats were divided into MPH-treated (n=6), ABS-treated (n=6) and control (n=8) groups. Laminectomy of the lumbar spine was performed in all animals and treatment groups were exposed to MPH and ABS while closure was applied in control group as per usual. Epidural fibrosis was evaluated in all groups macroscopically, histopathologically, biochemically and with electron microscopy four weeks later.

Results

Statistically, it was found that MPH-treated group had significantly less epidural fibrosis compared to ABS-treated and control groups.

Conclusion

We compared two hemostatic agents for their propensity to cause adhesions in the present study. Our results show that MPH significantly reduces epidural scar formation and dural adhesion in a rat model of laminectomy while ABS increases postoperative fibrosis.

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Keywords

Epidural fibrosis, Hemostasis, Laminectomy, Rats

About this article
Title

Hemostasis vs. epidural fibrosis?: A comparative study on an experimental rat model of laminectomy

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 50, No 5 (2016)

Pages

323-330

DOI

10.1016/j.pjnns.2016.05.002

Bibliographic record

Neurol Neurochir Pol 2016;50(5):323-330.

Keywords

Epidural fibrosis
Hemostasis
Laminectomy
Rats

Authors

Hakan Erdogan
Bilal Kelten
Matem Tuncdemir
Salime Pelin Erturkuner
Hafize Uzun
Alper Karaoglan

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