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Intravascular lymphoma mimicking multiple sclerosis
Affiliations- Clinical Department of Neurology, Rzeszow State Hospital No 2, Rzeszow, Poland
- Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Warzywna 1a, 35-959 Rzeszow, Poland
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Abstract
Diagnosis of relapsing–remitting multiple sclerosis requires demonstration disseminated symptoms in time and space on the basis of neurological assessment or magnetic resonance imaging findings. In addition, the diagnosis is conditioned by ruling out other conditions that may explain the clinical symptoms.
We describe the patient presenting in the initial stage of the disease neurological symptoms and magnetic resonance imaging lesions, that met criteria for relapsing–remitting multiple sclerosis diagnosis.
The patient was administered immunomodulatory treatment. However, the subsequent course of the disease tended to verify the diagnosis. Finally, the patient was diagnosed with intravascular B-cell lymphoma.
Intravascular lymphoma is a rare form of lymphoma characterized by the development of cancerous cells in the lumen of small and medium-sized blood vessels.
Due to the lack of characteristic biomarkers in laboratory tests and neuroimaging, the diagnosis is based on histopathological examination of the sample of the affected organ taken by biopsy. It should be consider in all cases of central nervous system damage of unknown, undiagnosed etiology.
Abstract
Diagnosis of relapsing–remitting multiple sclerosis requires demonstration disseminated symptoms in time and space on the basis of neurological assessment or magnetic resonance imaging findings. In addition, the diagnosis is conditioned by ruling out other conditions that may explain the clinical symptoms.
We describe the patient presenting in the initial stage of the disease neurological symptoms and magnetic resonance imaging lesions, that met criteria for relapsing–remitting multiple sclerosis diagnosis.
The patient was administered immunomodulatory treatment. However, the subsequent course of the disease tended to verify the diagnosis. Finally, the patient was diagnosed with intravascular B-cell lymphoma.
Intravascular lymphoma is a rare form of lymphoma characterized by the development of cancerous cells in the lumen of small and medium-sized blood vessels.
Due to the lack of characteristic biomarkers in laboratory tests and neuroimaging, the diagnosis is based on histopathological examination of the sample of the affected organ taken by biopsy. It should be consider in all cases of central nervous system damage of unknown, undiagnosed etiology.
Keywords
MRI, RIS, CSF, MS, RR–MS, CT, IVL, CNS
About this articleTitle
Intravascular lymphoma mimicking multiple sclerosis
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
313-317
Page views
224
Article views/downloads
605
DOI
10.1016/j.pjnns.2016.04.007
Bibliographic record
Neurol Neurochir Pol 2016;50(4):313-317.
Keywords
MRI
RIS
CSF
MS
RR–MS
CT
IVL
CNS
Authors
Grzegorz Kloc
Małgorzata Budziak
Agnieszka Więckiewicz
Mateusz Pleśniak
Halina Bartosik-Psujek
