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Cortical laminar necrosis following myocardial infarction
- Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy
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Abstract
The cortical laminar necrosis (CLN) is a permanent injury characterized by the selective delayed necrosis of the cerebral cortex, mainly of the third layer, and usually greater in the depths and sides of the sulci than over the crest of the gyri. The damage involves all cellular components – either neurons, glia cells and blood vessels – and results in a focal cortical band of pan-necrosis detectable in late sub-acute or chronic stages of reduced energy supply to the brain. The CLN has been described in different conditions as hypoxia, hypoglycemia and status epilepticus. At brain CT or MR scans it appears with pathognomonic highly hyperdense or T1-hyperintense lesions following the gyral anatomy of the cerebral cortex. We reported a case of CLN associated to myocardial infarct and discussed the underlying mechanisms.
Abstract
The cortical laminar necrosis (CLN) is a permanent injury characterized by the selective delayed necrosis of the cerebral cortex, mainly of the third layer, and usually greater in the depths and sides of the sulci than over the crest of the gyri. The damage involves all cellular components – either neurons, glia cells and blood vessels – and results in a focal cortical band of pan-necrosis detectable in late sub-acute or chronic stages of reduced energy supply to the brain. The CLN has been described in different conditions as hypoxia, hypoglycemia and status epilepticus. At brain CT or MR scans it appears with pathognomonic highly hyperdense or T1-hyperintense lesions following the gyral anatomy of the cerebral cortex. We reported a case of CLN associated to myocardial infarct and discussed the underlying mechanisms.
Keywords
Stroke, Cerebrovascular disease, Clinical neurology
Title
Cortical laminar necrosis following myocardial infarction
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
271-274
Page views
256
Article views/downloads
789
DOI
10.1016/j.pjnns.2016.03.001
Bibliographic record
Neurol Neurochir Pol 2016;50(4):271-274.
Keywords
Stroke
Cerebrovascular disease
Clinical neurology
Authors
Simona Lattanzi
Mauro Silvestrini
Leandro Provinciali