open access

Vol 50, No 4 (2016)
Original research articles
Submitted: 2015-10-23
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Bone metabolism and vitamin D status in patients with multiple sclerosis

Katarzyna Kępczyńska, Małgorzata Zajda, Zbigniew Lewandowski, Jerzy Przedlacki, Beata Zakrzewska-Pniewska
DOI: 10.1016/j.pjnns.2016.04.010
·
Neurol Neurochir Pol 2016;50(4):251-257.

open access

Vol 50, No 4 (2016)
Original research articles
Submitted: 2015-10-23

Abstract

Background

Vitamin D (VD), an important factor for bone health immobilization and immune regulation, has been shown to have low serum concentration in multiple sclerosis (MS) patients. Those patients have also multiple fracture risk factors, including progressive immobilization and long-term glucocorticoids treatment. The aim of the study was to analyze bone health (osteopenia or osteoporosis prevalence) and VD serum concentration in MS patients as well as the influence of disease activity and treatment on bone health.

Materials and methods

The study involved 72 MS patients: 52 women and 20 men. Mean age was 40.3±10.5 yrs, mean EDSS (Expanded Disability Status Scale) 3.3±1.9. Bone health was analyzed using standard densitometry in the lumbar spine and femoral neck. Serum levels of VD, calcium, phosphate and parathormone were assessed. We compared two groups of patients with multiple sclerosis: relapsing - remitting MS (RRMS) and progressive relapsing MS (PRMS).

Results

Densitometry revealed osteopenia in twenty-six (36.1%) patients and osteoporosis in eleven (15.3%), no bone fractures were presented. Sixty-eight MS patients (94.4%) had lower VD serum level if compared to population referential values. Thirteen patients (18.1%) had severe VD deficiency. Densitometry parameter (T-score of the lumbar spine) worsened with EDSS increase (r=−0.43, P=0.001). There was a statistically significant negative correlation between VD concentration and EDSS score (r=−0.31; P=0.009).

Conclusions

Our study indicates that patients with MS have high incidence of osteopenia and osteoporosis and vitamin D deficiency. Bone health disturbances studied by densitometry are related to the disability caused by MS.

Abstract

Background

Vitamin D (VD), an important factor for bone health immobilization and immune regulation, has been shown to have low serum concentration in multiple sclerosis (MS) patients. Those patients have also multiple fracture risk factors, including progressive immobilization and long-term glucocorticoids treatment. The aim of the study was to analyze bone health (osteopenia or osteoporosis prevalence) and VD serum concentration in MS patients as well as the influence of disease activity and treatment on bone health.

Materials and methods

The study involved 72 MS patients: 52 women and 20 men. Mean age was 40.3±10.5 yrs, mean EDSS (Expanded Disability Status Scale) 3.3±1.9. Bone health was analyzed using standard densitometry in the lumbar spine and femoral neck. Serum levels of VD, calcium, phosphate and parathormone were assessed. We compared two groups of patients with multiple sclerosis: relapsing - remitting MS (RRMS) and progressive relapsing MS (PRMS).

Results

Densitometry revealed osteopenia in twenty-six (36.1%) patients and osteoporosis in eleven (15.3%), no bone fractures were presented. Sixty-eight MS patients (94.4%) had lower VD serum level if compared to population referential values. Thirteen patients (18.1%) had severe VD deficiency. Densitometry parameter (T-score of the lumbar spine) worsened with EDSS increase (r=−0.43, P=0.001). There was a statistically significant negative correlation between VD concentration and EDSS score (r=−0.31; P=0.009).

Conclusions

Our study indicates that patients with MS have high incidence of osteopenia and osteoporosis and vitamin D deficiency. Bone health disturbances studied by densitometry are related to the disability caused by MS.

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Keywords

Bone health, Multiple sclerosis, Osteopenia, Osteoporosis, Vitamin D deficiency

About this article
Title

Bone metabolism and vitamin D status in patients with multiple sclerosis

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 50, No 4 (2016)

Pages

251-257

DOI

10.1016/j.pjnns.2016.04.010

Bibliographic record

Neurol Neurochir Pol 2016;50(4):251-257.

Keywords

Bone health
Multiple sclerosis
Osteopenia
Osteoporosis
Vitamin D deficiency

Authors

Katarzyna Kępczyńska
Małgorzata Zajda
Zbigniew Lewandowski
Jerzy Przedlacki
Beata Zakrzewska-Pniewska

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