open access
Medulloblastoma with suprasellar solitary massive metastasis: Case report
Affiliations- Department of Neurosurgery, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan
- Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Japan
- Department of Pathology, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan
- Department of Hematology-Oncology, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan
open access
Abstract
It is extremely rare for metastasised medulloblastoma to form a large tumour in the suprasellar region. We present a case of medulloblastoma with large suprasellar metastasis at initial presentation. A 3-year and 5-month-old boy presented with a 1-month history of vomiting and loss of appetite, and body weight. Computed tomography and magnetic resonance imaging revealed a 20mm×20mm mass in the suprasellar region and a 30mm×30mm mass in the fourth cerebral ventricle. We performed endoscopic biopsy of the suprasellar tumour, and subsequently totally removed the vermian tumour through a suboccipital craniotomy. The histopathological findings revealed that both the suprasellar and vermian tumours were classic type and non SHH/WNT type medulloblastoma. The postoperative course was uneventful. The patient showed complete remission after chemotherapy. The tumour in the suprasellar region was most likely metastatic from the vermis. Endoscopic biopsy of the tumour in the suprasellar region and total removal of the tumour in the vermis in a one-stage operation followed by intensive chemotherapy with reduced dose radiotherapy may provide a satisfactory outcome.
Abstract
It is extremely rare for metastasised medulloblastoma to form a large tumour in the suprasellar region. We present a case of medulloblastoma with large suprasellar metastasis at initial presentation. A 3-year and 5-month-old boy presented with a 1-month history of vomiting and loss of appetite, and body weight. Computed tomography and magnetic resonance imaging revealed a 20mm×20mm mass in the suprasellar region and a 30mm×30mm mass in the fourth cerebral ventricle. We performed endoscopic biopsy of the suprasellar tumour, and subsequently totally removed the vermian tumour through a suboccipital craniotomy. The histopathological findings revealed that both the suprasellar and vermian tumours were classic type and non SHH/WNT type medulloblastoma. The postoperative course was uneventful. The patient showed complete remission after chemotherapy. The tumour in the suprasellar region was most likely metastatic from the vermis. Endoscopic biopsy of the tumour in the suprasellar region and total removal of the tumour in the vermis in a one-stage operation followed by intensive chemotherapy with reduced dose radiotherapy may provide a satisfactory outcome.
Keywords
Medulloblastoma, Metastasis, Suprasellar region
About this articleTitle
Medulloblastoma with suprasellar solitary massive metastasis: Case report
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
211-214
Page views
377
Article views/downloads
430
DOI
10.1016/j.pjnns.2016.02.001
Bibliographic record
Neurol Neurochir Pol 2016;50(3):211-214.
Keywords
Medulloblastoma
Metastasis
Suprasellar region
Authors
Hiroaki Nagashima
Tatsuya Nagashima
Atsufumi Kawamura
Kazuki Yamamoto
Makiko Yoshida
Daiichiro Hasegawa
Yoshiyuki Kosaka
Eiji Kohmura
