open access

Vol 50, No 2 (2016)
Review article
Submitted: 2015-05-17
Get Citation

What you cannot get from routine MRI of MS patient and why – The growing need for atrophy assessment and seeing beyond the plaque

Marcin Hartel, Ewa Kluczewska, Krystyna Pierzchała, Monika Adamczyk-Sowa, Jacek Karpe
DOI: 10.1016/j.pjnns.2016.01.007
·
Neurol Neurochir Pol 2016;50(2):123-130.

open access

Vol 50, No 2 (2016)
Review article
Submitted: 2015-05-17

Abstract

Multiple sclerosis is a disease that still has not been fully understood and calls for better diagnostic procedures for the improvement of everyday patient care and drug development. Routine magnetic resonance examinations reveal demyelinating focal lesions, but they do not correlate sufficiently with the patients’ disability and cognitive impairment. For more than 100 years it has been known that demyelination affects not only white but also grey matter of the brain. Recent research has confirmed the serious consequences of grey matter pathology. Over the last several years, atrophy of the brain and especially of its grey matter has become a most promising marker of the patients’ clinical status. The paper discusses the concept and importance of atrophy assessment in relation to the standard magnetic resonance results.

Abstract

Multiple sclerosis is a disease that still has not been fully understood and calls for better diagnostic procedures for the improvement of everyday patient care and drug development. Routine magnetic resonance examinations reveal demyelinating focal lesions, but they do not correlate sufficiently with the patients’ disability and cognitive impairment. For more than 100 years it has been known that demyelination affects not only white but also grey matter of the brain. Recent research has confirmed the serious consequences of grey matter pathology. Over the last several years, atrophy of the brain and especially of its grey matter has become a most promising marker of the patients’ clinical status. The paper discusses the concept and importance of atrophy assessment in relation to the standard magnetic resonance results.

Get Citation

Keywords

Multiple sclerosis, Magnetic resonance imaging, Brain atrophy, Volumetric analysis

About this article
Title

What you cannot get from routine MRI of MS patient and why – The growing need for atrophy assessment and seeing beyond the plaque

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 50, No 2 (2016)

Pages

123-130

DOI

10.1016/j.pjnns.2016.01.007

Bibliographic record

Neurol Neurochir Pol 2016;50(2):123-130.

Keywords

Multiple sclerosis
Magnetic resonance imaging
Brain atrophy
Volumetric analysis

Authors

Marcin Hartel
Ewa Kluczewska
Krystyna Pierzchała
Monika Adamczyk-Sowa
Jacek Karpe

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