open access
A case report of patient with cerebellar variant of stiff person syndrome
Affiliations- Department of Neurology, The John Paul II Specialist Hospital, Krakow, Poland
- Department of Neurology, Medical University of Silesia, Faculty of Medicine, Katowice, Poland
- Nuclear Medicine Department, 5-th Clinical Military Hospital, Krakow, Poland
- Department of Neurology, University Hospital, Jagiellonian University Medical College, Krakow, Poland
open access
Abstract
Stiff person syndrome (SPS) is a rare autoimmune neurological disorder with antibodies against antigens involved in neurotransmission of gamma-aminobutyric acid (GABA). About 10% of patients with SPS may develop ataxia. This cerebellar variant is a distinct subset of SPS with more severe and complex clinical phenotype.
We report the clinical, neuropsychological and neuroradiological findings in a 39-year-old female with cerebellar variant of SPS.
Abstract
Stiff person syndrome (SPS) is a rare autoimmune neurological disorder with antibodies against antigens involved in neurotransmission of gamma-aminobutyric acid (GABA). About 10% of patients with SPS may develop ataxia. This cerebellar variant is a distinct subset of SPS with more severe and complex clinical phenotype.
We report the clinical, neuropsychological and neuroradiological findings in a 39-year-old female with cerebellar variant of SPS.
Keywords
Stiff person syndrome, Cerebellar ataxia, Cognitive impairment, Glutamic acid decarboxylase antibodies
About this articleTitle
A case report of patient with cerebellar variant of stiff person syndrome
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
59-62
Page views
368
Article views/downloads
993
DOI
10.1016/j.pjnns.2015.11.003
Bibliographic record
Neurol Neurochir Pol 2016;50(1):59-62.
Keywords
Stiff person syndrome
Cerebellar ataxia
Cognitive impairment
Glutamic acid decarboxylase antibodies
Authors
Ewa Maludzińska
Monika Rudzińska
Artur Stępień
Andrzej Szczudlik
