open access

Vol 50, No 1 (2016)
Original research articles
Submitted: 2015-06-01
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Comparison of biochemical response between the minimally invasive and standard open posterior lumbar interbody fusion

Petr Linzer, Michal Filip, Patrik Jurek, Tomáš Šálek, Miroslav Gajdoš, Jiří Jarkovský
DOI: 10.1016/j.pjnns.2015.10.008
·
Neurol Neurochir Pol 2016;50(1):16-23.

open access

Vol 50, No 1 (2016)
Original research articles
Submitted: 2015-06-01

Abstract

Background

The mini-invasive open posterior lumbar fusion procedure (mini PLIF) procedure is an alternative to standard open procedure (open PLIF) and is intended to reduce surgery-related trauma. The measuring of suitable biochemical factors enables objective comparison of the invasiveness of spinal surgery procedures.

Methods

Prospectively collected data on myoglobin, creatine kinase, interleukin-6, C-reactive protein levels and intensity of low back pain and radicular pain in one-level mini PLIF and open PLIF procedures were analysed. The mini PLIF and the open PLIF groups included 27 and 23 patients, respectively. The collection of blood samples and clinical data were performed preoperatively and on postoperative days 1, 3 and 7. The non-paired t-test was used for statistical evaluation.

Results

We did not found any statistically significant differences of myoglobin and creatine kinase levels between the groups. In the open PLIF group the IL-6 levels were significantly higher than in the mini PLIF group on postoperative day 3. CRP levels showed significant lower stress response in favour of the mini PLIF group on postoperative days 3 and 7. Levels of post-op low back pain on day 3 were significantly lower in mini PLIF group. Also intensity of radicular pain on day 1 and 3 were lower also mini PLIF group.

Conclusion

The extent of myonecrosis was comparable in both techniques. The analysis of the IL-6 and CRP levels showed significantly lower systemic inflammatory response in mini PLIF technique. The mini PLIF technique provides transiently lower postoperative pain levels.

Abstract

Background

The mini-invasive open posterior lumbar fusion procedure (mini PLIF) procedure is an alternative to standard open procedure (open PLIF) and is intended to reduce surgery-related trauma. The measuring of suitable biochemical factors enables objective comparison of the invasiveness of spinal surgery procedures.

Methods

Prospectively collected data on myoglobin, creatine kinase, interleukin-6, C-reactive protein levels and intensity of low back pain and radicular pain in one-level mini PLIF and open PLIF procedures were analysed. The mini PLIF and the open PLIF groups included 27 and 23 patients, respectively. The collection of blood samples and clinical data were performed preoperatively and on postoperative days 1, 3 and 7. The non-paired t-test was used for statistical evaluation.

Results

We did not found any statistically significant differences of myoglobin and creatine kinase levels between the groups. In the open PLIF group the IL-6 levels were significantly higher than in the mini PLIF group on postoperative day 3. CRP levels showed significant lower stress response in favour of the mini PLIF group on postoperative days 3 and 7. Levels of post-op low back pain on day 3 were significantly lower in mini PLIF group. Also intensity of radicular pain on day 1 and 3 were lower also mini PLIF group.

Conclusion

The extent of myonecrosis was comparable in both techniques. The analysis of the IL-6 and CRP levels showed significantly lower systemic inflammatory response in mini PLIF technique. The mini PLIF technique provides transiently lower postoperative pain levels.

Get Citation

Keywords

Creatine kinase, Interleukin-6, Lumbar interbody fusion, Minimally invasive approach, Myoglobin

About this article
Title

Comparison of biochemical response between the minimally invasive and standard open posterior lumbar interbody fusion

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 50, No 1 (2016)

Pages

16-23

DOI

10.1016/j.pjnns.2015.10.008

Bibliographic record

Neurol Neurochir Pol 2016;50(1):16-23.

Keywords

Creatine kinase
Interleukin-6
Lumbar interbody fusion
Minimally invasive approach
Myoglobin

Authors

Petr Linzer
Michal Filip
Patrik Jurek
Tomáš Šálek
Miroslav Gajdoš
Jiří Jarkovský

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