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Comparison of biochemical response between the minimally invasive and standard open posterior lumbar interbody fusion
Affiliations- Department of Neurosurgery, Bata Hospital, Zlín, Czech Republic
- Department of Biochemistry, Bata Hospital, Zlín, Czech Republic
- Department of Neurosurgery, Pavol Josef Šafárik University, Košice, Slovakia
- Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic
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Abstract
The mini-invasive open posterior lumbar fusion procedure (mini PLIF) procedure is an alternative to standard open procedure (open PLIF) and is intended to reduce surgery-related trauma. The measuring of suitable biochemical factors enables objective comparison of the invasiveness of spinal surgery procedures.
MethodsProspectively collected data on myoglobin, creatine kinase, interleukin-6, C-reactive protein levels and intensity of low back pain and radicular pain in one-level mini PLIF and open PLIF procedures were analysed. The mini PLIF and the open PLIF groups included 27 and 23 patients, respectively. The collection of blood samples and clinical data were performed preoperatively and on postoperative days 1, 3 and 7. The non-paired t-test was used for statistical evaluation.
ResultsWe did not found any statistically significant differences of myoglobin and creatine kinase levels between the groups. In the open PLIF group the IL-6 levels were significantly higher than in the mini PLIF group on postoperative day 3. CRP levels showed significant lower stress response in favour of the mini PLIF group on postoperative days 3 and 7. Levels of post-op low back pain on day 3 were significantly lower in mini PLIF group. Also intensity of radicular pain on day 1 and 3 were lower also mini PLIF group.
ConclusionThe extent of myonecrosis was comparable in both techniques. The analysis of the IL-6 and CRP levels showed significantly lower systemic inflammatory response in mini PLIF technique. The mini PLIF technique provides transiently lower postoperative pain levels.
Abstract
The mini-invasive open posterior lumbar fusion procedure (mini PLIF) procedure is an alternative to standard open procedure (open PLIF) and is intended to reduce surgery-related trauma. The measuring of suitable biochemical factors enables objective comparison of the invasiveness of spinal surgery procedures.
MethodsProspectively collected data on myoglobin, creatine kinase, interleukin-6, C-reactive protein levels and intensity of low back pain and radicular pain in one-level mini PLIF and open PLIF procedures were analysed. The mini PLIF and the open PLIF groups included 27 and 23 patients, respectively. The collection of blood samples and clinical data were performed preoperatively and on postoperative days 1, 3 and 7. The non-paired t-test was used for statistical evaluation.
ResultsWe did not found any statistically significant differences of myoglobin and creatine kinase levels between the groups. In the open PLIF group the IL-6 levels were significantly higher than in the mini PLIF group on postoperative day 3. CRP levels showed significant lower stress response in favour of the mini PLIF group on postoperative days 3 and 7. Levels of post-op low back pain on day 3 were significantly lower in mini PLIF group. Also intensity of radicular pain on day 1 and 3 were lower also mini PLIF group.
ConclusionThe extent of myonecrosis was comparable in both techniques. The analysis of the IL-6 and CRP levels showed significantly lower systemic inflammatory response in mini PLIF technique. The mini PLIF technique provides transiently lower postoperative pain levels.
Keywords
Creatine kinase, Interleukin-6, Lumbar interbody fusion, Minimally invasive approach, Myoglobin
About this articleTitle
Comparison of biochemical response between the minimally invasive and standard open posterior lumbar interbody fusion
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
16-23
Page views
359
Article views/downloads
611
DOI
10.1016/j.pjnns.2015.10.008
Bibliographic record
Neurol Neurochir Pol 2016;50(1):16-23.
Keywords
Creatine kinase
Interleukin-6
Lumbar interbody fusion
Minimally invasive approach
Myoglobin
Authors
Petr Linzer
Michal Filip
Patrik Jurek
Tomáš Šálek
Miroslav Gajdoš
Jiří Jarkovský
