open access

Vol 50, No 1 (2016)
Original research articles
Submitted: 2015-06-07
Get Citation

Diffusion tensor tractography imaging in pediatric epilepsy – A systematic review

Marta Szmuda, Tomasz Szmuda, Janusz Springer, Marianna Rogowska, Agnieszka Sabisz, Mirosława Dubaniewicz, Maria Mazurkiewicz-Bełdzińska
DOI: 10.1016/j.pjnns.2015.10.003
·
Neurol Neurochir Pol 2016;50(1):1-6.

open access

Vol 50, No 1 (2016)
Original research articles
Submitted: 2015-06-07

Abstract

Purpose

Recent years brought several experimental and clinical reports applying diffusion tensor tractography imaging (DTI) of the brain in epilepsy. This study was aimed to evaluate current evidence for adding the DTI sequence to the standard diagnostic magnetic resonance imaging (MRI) protocol in pediatric epilepsy.

Material and methods

Rapid and qualitative systematic review (RAE, Rapid Evidence Assessment), aggregating relevant studies from the recent 7 years. The PubMed database was hand searched for records containing terms “tractography AND epilepsy.” Only studies referring to children were included; studies were rated using “final quality of evidence.”

Results

Out of 144 screened records, relevant 101 were aggregated and reviewed. The synthesis was based on 73 studies. Case-control clinical studies were the majority of the material and comprised 43.8% of the material. Low ‘confirmability’ and low ‘applicability’ referred to 18 and 17 articles (29.5% and 27.9%), respectively. The sufficient quality of evidence supported performing DTI in temporal lobe epilepsy, malformations of cortical development and prior to a neurosurgery of epilepsy.

Conclusions

The qualitative RAE provides an interim estimate of the clinical relevance of quickly developing diagnostic methods. Based on the critical appraisal of current knowledge, adding the DTI sequence to the standard MRI protocol may be clinically beneficial in selected patient groups with childhood temporal lobe epilepsy or as a part of planning for an epilepsy surgery.

Abstract

Purpose

Recent years brought several experimental and clinical reports applying diffusion tensor tractography imaging (DTI) of the brain in epilepsy. This study was aimed to evaluate current evidence for adding the DTI sequence to the standard diagnostic magnetic resonance imaging (MRI) protocol in pediatric epilepsy.

Material and methods

Rapid and qualitative systematic review (RAE, Rapid Evidence Assessment), aggregating relevant studies from the recent 7 years. The PubMed database was hand searched for records containing terms “tractography AND epilepsy.” Only studies referring to children were included; studies were rated using “final quality of evidence.”

Results

Out of 144 screened records, relevant 101 were aggregated and reviewed. The synthesis was based on 73 studies. Case-control clinical studies were the majority of the material and comprised 43.8% of the material. Low ‘confirmability’ and low ‘applicability’ referred to 18 and 17 articles (29.5% and 27.9%), respectively. The sufficient quality of evidence supported performing DTI in temporal lobe epilepsy, malformations of cortical development and prior to a neurosurgery of epilepsy.

Conclusions

The qualitative RAE provides an interim estimate of the clinical relevance of quickly developing diagnostic methods. Based on the critical appraisal of current knowledge, adding the DTI sequence to the standard MRI protocol may be clinically beneficial in selected patient groups with childhood temporal lobe epilepsy or as a part of planning for an epilepsy surgery.

Get Citation

Keywords

Pediatric epilepsy, Diffusion tensor tractography, Systematic review

About this article
Title

Diffusion tensor tractography imaging in pediatric epilepsy – A systematic review

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 50, No 1 (2016)

Pages

1-6

DOI

10.1016/j.pjnns.2015.10.003

Bibliographic record

Neurol Neurochir Pol 2016;50(1):1-6.

Keywords

Pediatric epilepsy
Diffusion tensor tractography
Systematic review

Authors

Marta Szmuda
Tomasz Szmuda
Janusz Springer
Marianna Rogowska
Agnieszka Sabisz
Mirosława Dubaniewicz
Maria Mazurkiewicz-Bełdzińska

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: viamedica@viamedica.pl