open access

Vol 49, No 6 (2015)
Original research articles
Submitted: 2015-05-10
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Clinical course and management of intracranial meningiomas in neurofibromatosis type 2 patients

Arkadiusz Nowak, Tomasz Dziedzic, Tomasz Czernicki, Przemysław Kunert, Andrzej Marchel
DOI: 10.1016/j.pjnns.2015.08.007
·
Neurol Neurochir Pol 2015;49(6):367-372.

open access

Vol 49, No 6 (2015)
Original research articles
Submitted: 2015-05-10

Abstract

Objective

The aim of this study is to evaluate our surgical experience with intracranial meningiomas in NF2 patients and provide knowledge of the natural history of these lesions.

Methods

We included in the natural growth study patients with the diagnosis of NF2 who harbored intracranial meningiomas and were observed for at least 1 year. Tumors that were resected before achieving long-term follow-up were excluded from this analysis.

Results

We found 118 intracranial meningiomas in 34 patients in our series. 8 meningiomas in 7 patients were symptomatic. It was found that with an increase in tumor volume, brain edema and with the tumor location at the skull base, meningiomas are more likely to be symptomatic. Univariate analysis revealed that tumor growth was associated with a younger age at the onset of NF2-related symptoms, greater initial tumor volume, brain edema and with the presence of intracranial non-vestibular schwannoma. Multivariate analysis showed that the probability of tumor growth is associated with prolonged follow-up time. De novo meningiomas exhibited a significantly higher growth rate than other meningiomas. These tumors were more frequent in patients with intracranial non-vestibular schwannoma and with increasing length of meningioma observation.

Conclusion

Meningiomas occur in about half NF2 patients. Many of them exhibit slow growth and long remain asymptomatic, however, those associated with early onset of NF2 symptoms and other features of the disease severity should be monitored in case of clinical and radiological progression that may require surgical treatment.

Abstract

Objective

The aim of this study is to evaluate our surgical experience with intracranial meningiomas in NF2 patients and provide knowledge of the natural history of these lesions.

Methods

We included in the natural growth study patients with the diagnosis of NF2 who harbored intracranial meningiomas and were observed for at least 1 year. Tumors that were resected before achieving long-term follow-up were excluded from this analysis.

Results

We found 118 intracranial meningiomas in 34 patients in our series. 8 meningiomas in 7 patients were symptomatic. It was found that with an increase in tumor volume, brain edema and with the tumor location at the skull base, meningiomas are more likely to be symptomatic. Univariate analysis revealed that tumor growth was associated with a younger age at the onset of NF2-related symptoms, greater initial tumor volume, brain edema and with the presence of intracranial non-vestibular schwannoma. Multivariate analysis showed that the probability of tumor growth is associated with prolonged follow-up time. De novo meningiomas exhibited a significantly higher growth rate than other meningiomas. These tumors were more frequent in patients with intracranial non-vestibular schwannoma and with increasing length of meningioma observation.

Conclusion

Meningiomas occur in about half NF2 patients. Many of them exhibit slow growth and long remain asymptomatic, however, those associated with early onset of NF2 symptoms and other features of the disease severity should be monitored in case of clinical and radiological progression that may require surgical treatment.

Get Citation

Keywords

Meningioma, Natural history, Neurofibromatosis type 2

About this article
Title

Clinical course and management of intracranial meningiomas in neurofibromatosis type 2 patients

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 49, No 6 (2015)

Pages

367-372

DOI

10.1016/j.pjnns.2015.08.007

Bibliographic record

Neurol Neurochir Pol 2015;49(6):367-372.

Keywords

Meningioma
Natural history
Neurofibromatosis type 2

Authors

Arkadiusz Nowak
Tomasz Dziedzic
Tomasz Czernicki
Przemysław Kunert
Andrzej Marchel

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