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Neurological presentation of hemophagocytic lymphohistiocytosis
- Department of Neurology, Jagiellonian University Medical College, Krakow, Poland
- Department of Hematology, Jagiellonian University Medical College, Krakow, Poland
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Abstract
Hemophagocytic lymphohistiocytosis (HLH) is an inflammatory disorder arising from defects in critical regulatory pathways responsible for termination of inflammatory response.
We are presenting a case report of a 20-year-old male, admitted to the Department of Neurology because of left lower limb weakness and balance disturbances. After a few days of hospitalization, fever occurred. Laboratory tests revealed anemia, neutropenia, lymphopenia, and thrombocytopenia. The clinical course and laboratory tests results confirmed the diagnosis of HLH. In our opinion, the disorder in the presented case occurred due to severe chronic active Epstein–Barr virus infection syndrome. We are presenting the case of pure neurological onset of hemophagocytic lymphohistiocytosis in an adult patient.
Hemophagocytic lymphohistiocytosis, initially presenting with neurological symptoms, can occur in adult patients with irrelevant family history. It is a life-threatening but potentially curable condition requiring proper diagnostic and treatment management.
Abstract
Hemophagocytic lymphohistiocytosis (HLH) is an inflammatory disorder arising from defects in critical regulatory pathways responsible for termination of inflammatory response.
We are presenting a case report of a 20-year-old male, admitted to the Department of Neurology because of left lower limb weakness and balance disturbances. After a few days of hospitalization, fever occurred. Laboratory tests revealed anemia, neutropenia, lymphopenia, and thrombocytopenia. The clinical course and laboratory tests results confirmed the diagnosis of HLH. In our opinion, the disorder in the presented case occurred due to severe chronic active Epstein–Barr virus infection syndrome. We are presenting the case of pure neurological onset of hemophagocytic lymphohistiocytosis in an adult patient.
Hemophagocytic lymphohistiocytosis, initially presenting with neurological symptoms, can occur in adult patients with irrelevant family history. It is a life-threatening but potentially curable condition requiring proper diagnostic and treatment management.
Keywords
Hemophagocytic lymphohistiocytosis, Epstein–Barr virus infection, Polyneuropathy
Title
Neurological presentation of hemophagocytic lymphohistiocytosis
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
329-331
Page views
280
Article views/downloads
537
DOI
10.1016/j.pjnns.2015.07.001
Bibliographic record
Neurol Neurochir Pol 2015;49(5):329-331.
Keywords
Hemophagocytic lymphohistiocytosis
Epstein–Barr virus infection
Polyneuropathy
Authors
Żur-Wyrozumska Kamila
Rog Teresa
Mensah-Glanowska Patrycja
Szczudlik Andrzej