open access

Vol 49, No 5 (2015)
Case reports
Submitted: 2014-03-04
Get Citation

Neurological presentation of hemophagocytic lymphohistiocytosis

Żur-Wyrozumska Kamila, Rog Teresa, Mensah-Glanowska Patrycja, Szczudlik Andrzej
DOI: 10.1016/j.pjnns.2015.07.001
·
Neurol Neurochir Pol 2015;49(5):329-331.

open access

Vol 49, No 5 (2015)
Case reports
Submitted: 2014-03-04

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is an inflammatory disorder arising from defects in critical regulatory pathways responsible for termination of inflammatory response.

We are presenting a case report of a 20-year-old male, admitted to the Department of Neurology because of left lower limb weakness and balance disturbances. After a few days of hospitalization, fever occurred. Laboratory tests revealed anemia, neutropenia, lymphopenia, and thrombocytopenia. The clinical course and laboratory tests results confirmed the diagnosis of HLH. In our opinion, the disorder in the presented case occurred due to severe chronic active Epstein–Barr virus infection syndrome. We are presenting the case of pure neurological onset of hemophagocytic lymphohistiocytosis in an adult patient.

Hemophagocytic lymphohistiocytosis, initially presenting with neurological symptoms, can occur in adult patients with irrelevant family history. It is a life-threatening but potentially curable condition requiring proper diagnostic and treatment management.

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is an inflammatory disorder arising from defects in critical regulatory pathways responsible for termination of inflammatory response.

We are presenting a case report of a 20-year-old male, admitted to the Department of Neurology because of left lower limb weakness and balance disturbances. After a few days of hospitalization, fever occurred. Laboratory tests revealed anemia, neutropenia, lymphopenia, and thrombocytopenia. The clinical course and laboratory tests results confirmed the diagnosis of HLH. In our opinion, the disorder in the presented case occurred due to severe chronic active Epstein–Barr virus infection syndrome. We are presenting the case of pure neurological onset of hemophagocytic lymphohistiocytosis in an adult patient.

Hemophagocytic lymphohistiocytosis, initially presenting with neurological symptoms, can occur in adult patients with irrelevant family history. It is a life-threatening but potentially curable condition requiring proper diagnostic and treatment management.

Get Citation

Keywords

Hemophagocytic lymphohistiocytosis, Epstein–Barr virus infection, Polyneuropathy

About this article
Title

Neurological presentation of hemophagocytic lymphohistiocytosis

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 49, No 5 (2015)

Pages

329-331

DOI

10.1016/j.pjnns.2015.07.001

Bibliographic record

Neurol Neurochir Pol 2015;49(5):329-331.

Keywords

Hemophagocytic lymphohistiocytosis
Epstein–Barr virus infection
Polyneuropathy

Authors

Żur-Wyrozumska Kamila
Rog Teresa
Mensah-Glanowska Patrycja
Szczudlik Andrzej

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: viamedica@viamedica.pl