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Potential role of statins in the intracerebral hemorrhage and subarachnoid hemorrhage
Affiliations- Department of Neurology, Pomeranian Medical University, Szczecin, Poland
- Department of Gynaecology and Urogynaecology, Pomeranian Medical University, Szczecin, Poland
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Abstract
Statins are used in primary and secondary prevention of cardiovascular episodes. Most of recent studies regard ischemic stroke. There are more emerging results of studies suggesting usefulness of these drugs in the other types of stroke e.g. intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH). Searching for new methods of treatment is important, because both ICH and SAH lead to poor prognosis and severe psychomotor disability.
The unquestionable role of inflammatory factors in the pathogenesis of these disorders justifies considering statin treatment. Previous results are contradictory, thus in present study we review results of studies and try to explain the potential pathomechanism of statin use in hemorrhagic strokes.
Abstract
Statins are used in primary and secondary prevention of cardiovascular episodes. Most of recent studies regard ischemic stroke. There are more emerging results of studies suggesting usefulness of these drugs in the other types of stroke e.g. intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH). Searching for new methods of treatment is important, because both ICH and SAH lead to poor prognosis and severe psychomotor disability.
The unquestionable role of inflammatory factors in the pathogenesis of these disorders justifies considering statin treatment. Previous results are contradictory, thus in present study we review results of studies and try to explain the potential pathomechanism of statin use in hemorrhagic strokes.
Keywords
Statins, Intracerebral hemorrhage, Subarachnoid hemorrhage, Inflammation
About this articleTitle
Potential role of statins in the intracerebral hemorrhage and subarachnoid hemorrhage
Journal
Neurologia i Neurochirurgia Polska
Issue
Article type
Review Article
Pages
322-328
Page views
358
Article views/downloads
847
DOI
10.1016/j.pjnns.2015.07.007
Bibliographic record
Neurol Neurochir Pol 2015;49(5):322-328.
Keywords
Statins
Intracerebral hemorrhage
Subarachnoid hemorrhage
Inflammation
Authors
Dariusz Kotlęga
Monika Gołąb-Janowska
Marta Masztalewicz
Sylwester Ciećwież
Przemysław Nowacki
