open access

Vol 49, No 5 (2015)
Review article
Submitted: 2014-11-09
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Evolution of diagnostic criteria for multiple sclerosis

Joanna Przybek, Inga Gniatkowska, Dagmara Mirowska-Guzel, Anna Członkowska
DOI: 10.1016/j.pjnns.2015.07.006
·
Neurol Neurochir Pol 2015;49(5):313-321.

open access

Vol 49, No 5 (2015)
Review article
Submitted: 2014-11-09

Abstract

Multiple sclerosis is a chronic demyelinating disease of the central nervous system that occurs primarily in young adults. There is no single diagnostic test to recognize the disease. The diagnostic criteria, based on clinical examination and laboratory tests, have changed considerably over time. The first guidelines involved only the results of the patient's neurological examination. The diagnostic criteria developed by Poser in 1983 were based largely on the results of additional tests, including visual evoked potentials and analysis of cerebrospinal fluid. The McDonald criteria, developed in 2001and updated in 2005 and 2010, reflected the diagnostic breakthrough caused by widespread use of magnetic resonance imaging (MRI). Currently, the diagnosis depends largely on the results of the MRI examination. An early diagnosis is particularly important for starting disease-modifying treatments.

Abstract

Multiple sclerosis is a chronic demyelinating disease of the central nervous system that occurs primarily in young adults. There is no single diagnostic test to recognize the disease. The diagnostic criteria, based on clinical examination and laboratory tests, have changed considerably over time. The first guidelines involved only the results of the patient's neurological examination. The diagnostic criteria developed by Poser in 1983 were based largely on the results of additional tests, including visual evoked potentials and analysis of cerebrospinal fluid. The McDonald criteria, developed in 2001and updated in 2005 and 2010, reflected the diagnostic breakthrough caused by widespread use of magnetic resonance imaging (MRI). Currently, the diagnosis depends largely on the results of the MRI examination. An early diagnosis is particularly important for starting disease-modifying treatments.

Get Citation

Keywords

Multiple sclerosis, Poser criteria, McDonald criteria, MRI

About this article
Title

Evolution of diagnostic criteria for multiple sclerosis

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 49, No 5 (2015)

Pages

313-321

DOI

10.1016/j.pjnns.2015.07.006

Bibliographic record

Neurol Neurochir Pol 2015;49(5):313-321.

Keywords

Multiple sclerosis
Poser criteria
McDonald criteria
MRI

Authors

Joanna Przybek
Inga Gniatkowska
Dagmara Mirowska-Guzel
Anna Członkowska

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