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Evolution of diagnostic criteria for multiple sclerosis
Affiliations- chair and department of experimental and clinical pharmacology, medical university of warsaw
- 2nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
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Abstract
Multiple sclerosis is a chronic demyelinating disease of the central nervous system that occurs primarily in young adults. There is no single diagnostic test to recognize the disease. The diagnostic criteria, based on clinical examination and laboratory tests, have changed considerably over time. The first guidelines involved only the results of the patient's neurological examination. The diagnostic criteria developed by Poser in 1983 were based largely on the results of additional tests, including visual evoked potentials and analysis of cerebrospinal fluid. The McDonald criteria, developed in 2001and updated in 2005 and 2010, reflected the diagnostic breakthrough caused by widespread use of magnetic resonance imaging (MRI). Currently, the diagnosis depends largely on the results of the MRI examination. An early diagnosis is particularly important for starting disease-modifying treatments.
Abstract
Multiple sclerosis is a chronic demyelinating disease of the central nervous system that occurs primarily in young adults. There is no single diagnostic test to recognize the disease. The diagnostic criteria, based on clinical examination and laboratory tests, have changed considerably over time. The first guidelines involved only the results of the patient's neurological examination. The diagnostic criteria developed by Poser in 1983 were based largely on the results of additional tests, including visual evoked potentials and analysis of cerebrospinal fluid. The McDonald criteria, developed in 2001and updated in 2005 and 2010, reflected the diagnostic breakthrough caused by widespread use of magnetic resonance imaging (MRI). Currently, the diagnosis depends largely on the results of the MRI examination. An early diagnosis is particularly important for starting disease-modifying treatments.
Keywords
Multiple sclerosis, Poser criteria, McDonald criteria, MRI
About this articleTitle
Evolution of diagnostic criteria for multiple sclerosis
Journal
Neurologia i Neurochirurgia Polska
Issue
Article type
Review Article
Pages
313-321
Page views
484
Article views/downloads
568
DOI
10.1016/j.pjnns.2015.07.006
Bibliographic record
Neurol Neurochir Pol 2015;49(5):313-321.
Keywords
Multiple sclerosis
Poser criteria
McDonald criteria
MRI
Authors
Joanna Przybek
Inga Gniatkowska
Dagmara Mirowska-Guzel
Anna Członkowska
