open access

Vol 49, No 4 (2015)
Case report
Submitted: 2015-03-26
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Post-thrombolysis hemorrhage in a patient with hypothyroidism and acute ischemic stroke: Case report

Furong Gu, Jie Qin, Rongjie Chen, Xiaolin Xu
DOI: 10.1016/j.pjnns.2015.05.002
·
Neurol Neurochir Pol 2015;49(4):290-294.

open access

Vol 49, No 4 (2015)
Case report
Submitted: 2015-03-26

Abstract

Thrombolytic treatment with intravenous recombinant tissue plasminogen activator (rtPA) is an effective treatment for acute ischemic stroke. However, its effectiveness and risks in patients with hypothyroidism have not been reported. Here, we report the case of hemorrhagic transformation after intravenous rtPA thrombolysis treatment in a patient with acute ischemic stroke and hypothyroidism. An apparent edema formed around the hematoma and progressively worsened. He also developed lung infection, electrolyte imbalance, and abnormal liver and kidney functions, and eventually died within 1 month of symptom onset. Thus, our observations suggest that caution should be exercised for the administration of intravenous rtPA thrombolysis to patients with hypothyroidism.

Abstract

Thrombolytic treatment with intravenous recombinant tissue plasminogen activator (rtPA) is an effective treatment for acute ischemic stroke. However, its effectiveness and risks in patients with hypothyroidism have not been reported. Here, we report the case of hemorrhagic transformation after intravenous rtPA thrombolysis treatment in a patient with acute ischemic stroke and hypothyroidism. An apparent edema formed around the hematoma and progressively worsened. He also developed lung infection, electrolyte imbalance, and abnormal liver and kidney functions, and eventually died within 1 month of symptom onset. Thus, our observations suggest that caution should be exercised for the administration of intravenous rtPA thrombolysis to patients with hypothyroidism.

Get Citation

Keywords

Hypothyroidism, Thrombolysis, Recombinant tissue plasminogen activator, Acute ischemic stroke, Edema

About this article
Title

Post-thrombolysis hemorrhage in a patient with hypothyroidism and acute ischemic stroke: Case report

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 49, No 4 (2015)

Pages

290-294

DOI

10.1016/j.pjnns.2015.05.002

Bibliographic record

Neurol Neurochir Pol 2015;49(4):290-294.

Keywords

Hypothyroidism
Thrombolysis
Recombinant tissue plasminogen activator
Acute ischemic stroke
Edema

Authors

Furong Gu
Jie Qin
Rongjie Chen
Xiaolin Xu

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