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Post-thrombolysis hemorrhage in a patient with hypothyroidism and acute ischemic stroke: Case report
Affiliations- Neurology Department, Tianjin Huanhu Hospital, Tianjin, China
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Abstract
Thrombolytic treatment with intravenous recombinant tissue plasminogen activator (rtPA) is an effective treatment for acute ischemic stroke. However, its effectiveness and risks in patients with hypothyroidism have not been reported. Here, we report the case of hemorrhagic transformation after intravenous rtPA thrombolysis treatment in a patient with acute ischemic stroke and hypothyroidism. An apparent edema formed around the hematoma and progressively worsened. He also developed lung infection, electrolyte imbalance, and abnormal liver and kidney functions, and eventually died within 1 month of symptom onset. Thus, our observations suggest that caution should be exercised for the administration of intravenous rtPA thrombolysis to patients with hypothyroidism.
Abstract
Thrombolytic treatment with intravenous recombinant tissue plasminogen activator (rtPA) is an effective treatment for acute ischemic stroke. However, its effectiveness and risks in patients with hypothyroidism have not been reported. Here, we report the case of hemorrhagic transformation after intravenous rtPA thrombolysis treatment in a patient with acute ischemic stroke and hypothyroidism. An apparent edema formed around the hematoma and progressively worsened. He also developed lung infection, electrolyte imbalance, and abnormal liver and kidney functions, and eventually died within 1 month of symptom onset. Thus, our observations suggest that caution should be exercised for the administration of intravenous rtPA thrombolysis to patients with hypothyroidism.
Keywords
Hypothyroidism, Thrombolysis, Recombinant tissue plasminogen activator, Acute ischemic stroke, Edema
About this articleTitle
Post-thrombolysis hemorrhage in a patient with hypothyroidism and acute ischemic stroke: Case report
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
290-294
Page views
264
Article views/downloads
514
DOI
10.1016/j.pjnns.2015.05.002
Bibliographic record
Neurol Neurochir Pol 2015;49(4):290-294.
Keywords
Hypothyroidism
Thrombolysis
Recombinant tissue plasminogen activator
Acute ischemic stroke
Edema
Authors
Furong Gu
Jie Qin
Rongjie Chen
Xiaolin Xu
