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Gender specific association of decreased bone mineral density in patients with epilepsy
Affiliations- Department of Neurology, University Hospital of Ioannina, Ioannina, Greece
- Department of Nuclear Medicine, Medical School, University Hospital of Ioannina, Greece, Ioannina, Greece
- Department of Medical Physics, University Hospital of Ioannina, Ioannina, Greece
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Abstract
To evaluate whether epilepsy or certain antiepileptic drugs render patients prone to develop low bone mineral density (BMD) and osteoporosis risk.
MethodsThirty-eight (27 males, 11 females) consecutive adult epileptic patients receiving antiepileptic drugs (AEDs) and 71 control individuals matched for race, gender, age and body mass index (BMI) were subjected to dual energy X-ray absorptiometry (DXA).
ResultsThe mean lumbar spine and total hip BMD values were lower in the patients compared to control group (0.90±0.24g/cm2 vs 1.04±0.14g/cm2, p<0.001 and 0.92±0.14g/cm2 vs 0.99±0.13g/cm2, p=0.02, respectively). At the same skeletal sites, male patients had significantly reduced BMD compared to control males (0.90±0.21g/cm2 vs 1.03±0.15g/cm2, p=0.004 and 0.93±0.14g/cm2 vs 1.02±0.13g/cm2, p=0.009, respectively) while there was a trend but no significant differences in females. This BMD reduction was independent of AED type.
ConclusionAdult epileptic, predominantly male patients have lower BMD and could be screened with densitometry for early diagnosis and prevention of osteoporosis.
Abstract
To evaluate whether epilepsy or certain antiepileptic drugs render patients prone to develop low bone mineral density (BMD) and osteoporosis risk.
MethodsThirty-eight (27 males, 11 females) consecutive adult epileptic patients receiving antiepileptic drugs (AEDs) and 71 control individuals matched for race, gender, age and body mass index (BMI) were subjected to dual energy X-ray absorptiometry (DXA).
ResultsThe mean lumbar spine and total hip BMD values were lower in the patients compared to control group (0.90±0.24g/cm2 vs 1.04±0.14g/cm2, p<0.001 and 0.92±0.14g/cm2 vs 0.99±0.13g/cm2, p=0.02, respectively). At the same skeletal sites, male patients had significantly reduced BMD compared to control males (0.90±0.21g/cm2 vs 1.03±0.15g/cm2, p=0.004 and 0.93±0.14g/cm2 vs 1.02±0.13g/cm2, p=0.009, respectively) while there was a trend but no significant differences in females. This BMD reduction was independent of AED type.
ConclusionAdult epileptic, predominantly male patients have lower BMD and could be screened with densitometry for early diagnosis and prevention of osteoporosis.
Keywords
Epilepsy, Bone mineral density, X-ray absorptiometry, Antiepileptic drugs
About this articleTitle
Gender specific association of decreased bone mineral density in patients with epilepsy
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
267-271
Page views
194
Article views/downloads
301
DOI
10.1016/j.pjnns.2015.06.007
Bibliographic record
Neurol Neurochir Pol 2015;49(4):267-271.
Keywords
Epilepsy
Bone mineral density
X-ray absorptiometry
Antiepileptic drugs
Authors
Sofia Markoula
Chrissa Sioka
Thomas Exarchopoulos
Dimitrios Chatzistefanidis
John Kalef-Ezra
Andreas Fotopoulos
Athanassios P. Kyritsis
