Vol 49, No 4 (2015)

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Gender specific association of decreased bone mineral density in patients with epilepsy

Sofia Markoula1, Chrissa Sioka2, Thomas Exarchopoulos2, Dimitrios Chatzistefanidis1, John Kalef-Ezra3, Andreas Fotopoulos2, Athanassios P. Kyritsis1
DOI: 10.1016/j.pjnns.2015.06.007
Neurol Neurochir Pol 2015;49(4):267-271.



To evaluate whether epilepsy or certain antiepileptic drugs render patients prone to develop low bone mineral density (BMD) and osteoporosis risk.


Thirty-eight (27 males, 11 females) consecutive adult epileptic patients receiving antiepileptic drugs (AEDs) and 71 control individuals matched for race, gender, age and body mass index (BMI) were subjected to dual energy X-ray absorptiometry (DXA).


The mean lumbar spine and total hip BMD values were lower in the patients compared to control group (0.90±0.24g/cm2 vs 1.04±0.14g/cm2, p<0.001 and 0.92±0.14g/cm2 vs 0.99±0.13g/cm2, p=0.02, respectively). At the same skeletal sites, male patients had significantly reduced BMD compared to control males (0.90±0.21g/cm2 vs 1.03±0.15g/cm2, p=0.004 and 0.93±0.14g/cm2 vs 1.02±0.13g/cm2, p=0.009, respectively) while there was a trend but no significant differences in females. This BMD reduction was independent of AED type.


Adult epileptic, predominantly male patients have lower BMD and could be screened with densitometry for early diagnosis and prevention of osteoporosis.

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Neurologia i Neurochirurgia Polska