open access

Vol 49, No 4 (2015)
Original research articles
Submitted: 2015-02-23
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Gender specific association of decreased bone mineral density in patients with epilepsy

Sofia Markoula, Chrissa Sioka, Thomas Exarchopoulos, Dimitrios Chatzistefanidis, John Kalef-Ezra, Andreas Fotopoulos, Athanassios P. Kyritsis
DOI: 10.1016/j.pjnns.2015.06.007
·
Neurol Neurochir Pol 2015;49(4):267-271.

open access

Vol 49, No 4 (2015)
Original research articles
Submitted: 2015-02-23

Abstract

Objective

To evaluate whether epilepsy or certain antiepileptic drugs render patients prone to develop low bone mineral density (BMD) and osteoporosis risk.

Methods

Thirty-eight (27 males, 11 females) consecutive adult epileptic patients receiving antiepileptic drugs (AEDs) and 71 control individuals matched for race, gender, age and body mass index (BMI) were subjected to dual energy X-ray absorptiometry (DXA).

Results

The mean lumbar spine and total hip BMD values were lower in the patients compared to control group (0.90±0.24g/cm2 vs 1.04±0.14g/cm2, p<0.001 and 0.92±0.14g/cm2 vs 0.99±0.13g/cm2, p=0.02, respectively). At the same skeletal sites, male patients had significantly reduced BMD compared to control males (0.90±0.21g/cm2 vs 1.03±0.15g/cm2, p=0.004 and 0.93±0.14g/cm2 vs 1.02±0.13g/cm2, p=0.009, respectively) while there was a trend but no significant differences in females. This BMD reduction was independent of AED type.

Conclusion

Adult epileptic, predominantly male patients have lower BMD and could be screened with densitometry for early diagnosis and prevention of osteoporosis.

Abstract

Objective

To evaluate whether epilepsy or certain antiepileptic drugs render patients prone to develop low bone mineral density (BMD) and osteoporosis risk.

Methods

Thirty-eight (27 males, 11 females) consecutive adult epileptic patients receiving antiepileptic drugs (AEDs) and 71 control individuals matched for race, gender, age and body mass index (BMI) were subjected to dual energy X-ray absorptiometry (DXA).

Results

The mean lumbar spine and total hip BMD values were lower in the patients compared to control group (0.90±0.24g/cm2 vs 1.04±0.14g/cm2, p<0.001 and 0.92±0.14g/cm2 vs 0.99±0.13g/cm2, p=0.02, respectively). At the same skeletal sites, male patients had significantly reduced BMD compared to control males (0.90±0.21g/cm2 vs 1.03±0.15g/cm2, p=0.004 and 0.93±0.14g/cm2 vs 1.02±0.13g/cm2, p=0.009, respectively) while there was a trend but no significant differences in females. This BMD reduction was independent of AED type.

Conclusion

Adult epileptic, predominantly male patients have lower BMD and could be screened with densitometry for early diagnosis and prevention of osteoporosis.

Get Citation

Keywords

Epilepsy, Bone mineral density, X-ray absorptiometry, Antiepileptic drugs

About this article
Title

Gender specific association of decreased bone mineral density in patients with epilepsy

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 49, No 4 (2015)

Pages

267-271

DOI

10.1016/j.pjnns.2015.06.007

Bibliographic record

Neurol Neurochir Pol 2015;49(4):267-271.

Keywords

Epilepsy
Bone mineral density
X-ray absorptiometry
Antiepileptic drugs

Authors

Sofia Markoula
Chrissa Sioka
Thomas Exarchopoulos
Dimitrios Chatzistefanidis
John Kalef-Ezra
Andreas Fotopoulos
Athanassios P. Kyritsis

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