open access

Vol 49, No 4 (2015)
Original research articles
Submitted: 2014-10-20
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Clinicopathologic features of sporadic inclusion body myositis in China

Ke Li, Chuanqiang Pu, Xusheng Huang, Jiexiao Liu, Yanling Mao, Xianghui Lu
DOI: 10.1016/j.pjnns.2015.06.004
·
Neurol Neurochir Pol 2015;49(4):245-250.

open access

Vol 49, No 4 (2015)
Original research articles
Submitted: 2014-10-20

Abstract

This study is to investigate the clinical and pathologic features of sporadic inclusion body myositis (sIBM) in China. We retrospectively evaluated the clinical and pathological features of consecutive patients in our department between January 1986 to May 2012. Total 28 cases of sIBM (20 males, 8 females, mean age was 56.93±8.79) were obtained by review of all 4099 muscle biopsy reports. The proportion of sIBM was 0.68% (28/4099) in China. Muscle weakness of quadriceps appeared 100% in 28 cases, while conspicuous atrophy of quadriceps appeared only in five cases (17.86%). Creatase values of 28 patients with sIBM were normal or mildly elevated. Muscle biopsies showed that atrophic fibers resembled more frequent in small angular and irregular shape (82.14%), less common in small round shape (17.86%). Rimmed vacuoles resembled crack (67.86%) and round (32.14%) shape. Mononuclear cell invasion into necrotic muscle fibers (35.71%) was more frequent than non-necrotic muscle fibers (7.14%). sIBM was still a rare disease in China compared to other countries. There were some certain specific pathological characteristics existed in Chinese sIBM patients.

Abstract

This study is to investigate the clinical and pathologic features of sporadic inclusion body myositis (sIBM) in China. We retrospectively evaluated the clinical and pathological features of consecutive patients in our department between January 1986 to May 2012. Total 28 cases of sIBM (20 males, 8 females, mean age was 56.93±8.79) were obtained by review of all 4099 muscle biopsy reports. The proportion of sIBM was 0.68% (28/4099) in China. Muscle weakness of quadriceps appeared 100% in 28 cases, while conspicuous atrophy of quadriceps appeared only in five cases (17.86%). Creatase values of 28 patients with sIBM were normal or mildly elevated. Muscle biopsies showed that atrophic fibers resembled more frequent in small angular and irregular shape (82.14%), less common in small round shape (17.86%). Rimmed vacuoles resembled crack (67.86%) and round (32.14%) shape. Mononuclear cell invasion into necrotic muscle fibers (35.71%) was more frequent than non-necrotic muscle fibers (7.14%). sIBM was still a rare disease in China compared to other countries. There were some certain specific pathological characteristics existed in Chinese sIBM patients.

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Keywords

Sporadic inclusion body myositis, Rimmed vacuole, Inclusion body granule, Chinese population

About this article
Title

Clinicopathologic features of sporadic inclusion body myositis in China

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 49, No 4 (2015)

Pages

245-250

DOI

10.1016/j.pjnns.2015.06.004

Bibliographic record

Neurol Neurochir Pol 2015;49(4):245-250.

Keywords

Sporadic inclusion body myositis
Rimmed vacuole
Inclusion body granule
Chinese population

Authors

Ke Li
Chuanqiang Pu
Xusheng Huang
Jiexiao Liu
Yanling Mao
Xianghui Lu

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