open access

Vol 49, No 4 (2015)
Original research articles
Submitted: 2015-03-10
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Is descriptive writing useful in the differential diagnosis of logopenic variant of primary progressive aphasia, Alzheimer's disease and mild cognitive impairment?

Emilia J. Sitek, Anna Barczak, Klaudia Kluj-Kozłowska, Marcin Kozłowski, Maria Barcikowska, Jarosław Sławek
DOI: 10.1016/j.pjnns.2015.06.001
·
Neurol Neurochir Pol 2015;49(4):239-244.

open access

Vol 49, No 4 (2015)
Original research articles
Submitted: 2015-03-10

Abstract

Current classification of primary progressive aphasia (PPA) encompasses three variants: non-fluent (nfvPPA), semantic (svPPA) and logopenic (lvPPA). Previously lvPPA was regarded as aphasic form of Alzheimer's disease (AD). However, not all patients with lvPPA phenotype present with AD pathology. Despite abundant literature on differentiation of lvPPA from svPPA and nfvPPA, studies comparing lvPPA with AD and mild cognitive impairment (MCI) are scarce. This study aimed at analyzing written descriptive output in lvPPA, AD and MCI. Thirty-five patients participated in the study: 9 with lvPPA, 13 with AD and 13 with MCI. Most aspects of writing performance were comparable in three groups. However, letter insertion errors appeared in 44% patients with lvPPA, while they were absent in AD and MCI. Patients with lvPPA used more verbs than patients with AD. Writing profile may complement other neuropsychological assessment results in the differential diagnosis of lvPPA. Letter insertion errors and frequent verb use may raise a query of lvPPA.

Abstract

Current classification of primary progressive aphasia (PPA) encompasses three variants: non-fluent (nfvPPA), semantic (svPPA) and logopenic (lvPPA). Previously lvPPA was regarded as aphasic form of Alzheimer's disease (AD). However, not all patients with lvPPA phenotype present with AD pathology. Despite abundant literature on differentiation of lvPPA from svPPA and nfvPPA, studies comparing lvPPA with AD and mild cognitive impairment (MCI) are scarce. This study aimed at analyzing written descriptive output in lvPPA, AD and MCI. Thirty-five patients participated in the study: 9 with lvPPA, 13 with AD and 13 with MCI. Most aspects of writing performance were comparable in three groups. However, letter insertion errors appeared in 44% patients with lvPPA, while they were absent in AD and MCI. Patients with lvPPA used more verbs than patients with AD. Writing profile may complement other neuropsychological assessment results in the differential diagnosis of lvPPA. Letter insertion errors and frequent verb use may raise a query of lvPPA.

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Keywords

Logopenic progressive aphasia, Primary progressive aphasia, Mild cognitive impairment, Alzheimer' s disease, Agraphia

About this article
Title

Is descriptive writing useful in the differential diagnosis of logopenic variant of primary progressive aphasia, Alzheimer's disease and mild cognitive impairment?

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 49, No 4 (2015)

Pages

239-244

DOI

10.1016/j.pjnns.2015.06.001

Bibliographic record

Neurol Neurochir Pol 2015;49(4):239-244.

Keywords

Logopenic progressive aphasia
Primary progressive aphasia
Mild cognitive impairment
Alzheimer's disease
Agraphia

Authors

Emilia J. Sitek
Anna Barczak
Klaudia Kluj-Kozłowska
Marcin Kozłowski
Maria Barcikowska
Jarosław Sławek

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