open access
Intracranial bleedings in patients on long-term anticoagulant treatment: Benefits from oral thrombin and factor Xa inhibitors in clinical practice
- Chair & Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland
- Diagnostic and Treatment Centre INTERLAB, Poznan, Poland
- Institute of Cardiology, Jagiellonian University School of Medicine and John Paul II Hospital, Krakow, Poland
open access
Abstract
Dabigatran, a direct thrombin inhibitor and activated factor X inhibitors, rivaroxaban and apixaban, used in the prevention of stroke or systemic embolism in patients with nonvalvular atrial fibrillation (AF), have several advantages over vitamin K antagonists (VKAs). The non-vitamin K oral anticoagulants (NOACs) have been shown to reduce the risk of intracranial bleedings by 50%. The current review summarizes the available data on the epidemiology, mechanisms and treatment of intracranial bleedings observed on oral anticoagulation with the focus on the specificity of NOACs in this context.
Abstract
Dabigatran, a direct thrombin inhibitor and activated factor X inhibitors, rivaroxaban and apixaban, used in the prevention of stroke or systemic embolism in patients with nonvalvular atrial fibrillation (AF), have several advantages over vitamin K antagonists (VKAs). The non-vitamin K oral anticoagulants (NOACs) have been shown to reduce the risk of intracranial bleedings by 50%. The current review summarizes the available data on the epidemiology, mechanisms and treatment of intracranial bleedings observed on oral anticoagulation with the focus on the specificity of NOACs in this context.
Keywords
Non-vitamin K oral anticoagulant, Intracranial bleeding, Stroke
Title
Intracranial bleedings in patients on long-term anticoagulant treatment: Benefits from oral thrombin and factor Xa inhibitors in clinical practice
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
171-179
Page views
646
Article views/downloads
344
DOI
10.1016/j.pjnns.2015.04.007
Bibliographic record
Neurol Neurochir Pol 2015;49(3):171-179.
Keywords
Non-vitamin K oral anticoagulant
Intracranial bleeding
Stroke
Authors
Maria Łukasik
Krystyna Zawilska
Anetta Undas