open access

Vol 49, No 3 (2015)
Review articles
Submitted: 2015-01-26
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Intracranial bleedings in patients on long-term anticoagulant treatment: Benefits from oral thrombin and factor Xa inhibitors in clinical practice

Maria Łukasik, Krystyna Zawilska, Anetta Undas
DOI: 10.1016/j.pjnns.2015.04.007
·
Neurol Neurochir Pol 2015;49(3):171-179.

open access

Vol 49, No 3 (2015)
Review articles
Submitted: 2015-01-26

Abstract

Dabigatran, a direct thrombin inhibitor and activated factor X inhibitors, rivaroxaban and apixaban, used in the prevention of stroke or systemic embolism in patients with nonvalvular atrial fibrillation (AF), have several advantages over vitamin K antagonists (VKAs). The non-vitamin K oral anticoagulants (NOACs) have been shown to reduce the risk of intracranial bleedings by 50%. The current review summarizes the available data on the epidemiology, mechanisms and treatment of intracranial bleedings observed on oral anticoagulation with the focus on the specificity of NOACs in this context.

Abstract

Dabigatran, a direct thrombin inhibitor and activated factor X inhibitors, rivaroxaban and apixaban, used in the prevention of stroke or systemic embolism in patients with nonvalvular atrial fibrillation (AF), have several advantages over vitamin K antagonists (VKAs). The non-vitamin K oral anticoagulants (NOACs) have been shown to reduce the risk of intracranial bleedings by 50%. The current review summarizes the available data on the epidemiology, mechanisms and treatment of intracranial bleedings observed on oral anticoagulation with the focus on the specificity of NOACs in this context.

Get Citation

Keywords

Non-vitamin K oral anticoagulant, Intracranial bleeding, Stroke

About this article
Title

Intracranial bleedings in patients on long-term anticoagulant treatment: Benefits from oral thrombin and factor Xa inhibitors in clinical practice

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 49, No 3 (2015)

Pages

171-179

DOI

10.1016/j.pjnns.2015.04.007

Bibliographic record

Neurol Neurochir Pol 2015;49(3):171-179.

Keywords

Non-vitamin K oral anticoagulant
Intracranial bleeding
Stroke

Authors

Maria Łukasik
Krystyna Zawilska
Anetta Undas

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