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Progressive subacute Miller-Fisher syndrome successfully treated with plasmapheresis
Affiliations- Department of Neurology, Wrocław Medical University, Wrocław, Poland
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Abstract
Miller-Fisher Syndrome (MFS) is a rare acute polyneuropathy composed of the clinical triad of ataxia, areflexia and ophthalmoplegia, with a monophasic, self-limited course and spontaneous improvement.
Case reportThe authors present a 65-year-old man with Miller-Fisher syndrome consisting of bilateral ophthalmoplegia, trigeminal and facial nerve palsy, mild ataxia and peripheral neuropathy. The disease had a progressive, subacute course within 3 months. A high titer of anti-GQ1b antibodies was detected. As a result of plasmapheresis, complete recovery was achieved.
ConclusionsThe presented case was atypical in its clinical course and treatment. It could support the theory of the continuity between MFS, Bickerstaff brainstem encephalitis (BBE), and Guillain–Barré syndrome (GBS).
Abstract
Miller-Fisher Syndrome (MFS) is a rare acute polyneuropathy composed of the clinical triad of ataxia, areflexia and ophthalmoplegia, with a monophasic, self-limited course and spontaneous improvement.
Case reportThe authors present a 65-year-old man with Miller-Fisher syndrome consisting of bilateral ophthalmoplegia, trigeminal and facial nerve palsy, mild ataxia and peripheral neuropathy. The disease had a progressive, subacute course within 3 months. A high titer of anti-GQ1b antibodies was detected. As a result of plasmapheresis, complete recovery was achieved.
ConclusionsThe presented case was atypical in its clinical course and treatment. It could support the theory of the continuity between MFS, Bickerstaff brainstem encephalitis (BBE), and Guillain–Barré syndrome (GBS).
Keywords
Anti-GQ1b antibody, Miller-Fisher syndrome, Plasmapheresis
About this articleTitle
Progressive subacute Miller-Fisher syndrome successfully treated with plasmapheresis
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
137-138
Page views
394
Article views/downloads
599
DOI
10.1016/j.pjnns.2015.03.002
Bibliographic record
Neurol Neurochir Pol 2015;49(2):137-138.
Keywords
Anti-GQ1b antibody
Miller-Fisher syndrome
Plasmapheresis
Authors
Maria Ejma
Marta Waliszewska-Prosół
Anna Hofman
Sławomir Budrewicz
Ryszard Podemski
Małgorzata Bilińska
Magdalena Koszewicz
