Vol 49, No 2 (2015)

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Progressive subacute Miller-Fisher syndrome successfully treated with plasmapheresis

Maria Ejma1, Marta Waliszewska-Prosół1, Anna Hofman1, Sławomir Budrewicz1, Ryszard Podemski1, Małgorzata Bilińska1, Magdalena Koszewicz1
DOI: 10.1016/j.pjnns.2015.03.002
Neurol Neurochir Pol 2015;49(2):137-138.



Miller-Fisher Syndrome (MFS) is a rare acute polyneuropathy composed of the clinical triad of ataxia, areflexia and ophthalmoplegia, with a monophasic, self-limited course and spontaneous improvement.

Case report

The authors present a 65-year-old man with Miller-Fisher syndrome consisting of bilateral ophthalmoplegia, trigeminal and facial nerve palsy, mild ataxia and peripheral neuropathy. The disease had a progressive, subacute course within 3 months. A high titer of anti-GQ1b antibodies was detected. As a result of plasmapheresis, complete recovery was achieved.


The presented case was atypical in its clinical course and treatment. It could support the theory of the continuity between MFS, Bickerstaff brainstem encephalitis (BBE), and Guillain–Barré syndrome (GBS).

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Neurologia i Neurochirurgia Polska