open access

Vol 49, No 2 (2015)
Original research articles
Submitted: 2015-01-04
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Impact of hypertension and smoking on the rupture of intracranial aneurysms and their joint effect

Huibin Kang, Tangming Peng, Zenghui Qian, Youxiang Li, Chuhan Jiang, Wenjun Ji, Jing Wu, Wenjuan Xu, Xiaolong Wen, Aihua Liu
DOI: 10.1016/j.pjnns.2015.03.005
·
Neurol Neurochir Pol 2015;49(2):121-125.

open access

Vol 49, No 2 (2015)
Original research articles
Submitted: 2015-01-04

Abstract

Background

In general population, the prevalence of intracranial aneurysm reaches as high as three percent. The goal of the study was to analyze retrospectively the independent risk factors for the rupture of intracranial aneurysms and their joint effect.

Methods

The records and angiographies of continuous 519 intracranial aneurysm patients treated at our center between February 2013 and July 2014 were retrospectively analyzed. Ruptured group and unruptured group were included in the study according to their clinical and imaging information. Univariate analysis and multivariate logistic regression analysis was used to identified independent risk factors for the rupture of intracranial aneurysms. We assessed the joint effect of independent risk factors for the rupture of intracranial aneurysms with an additional logistic regression analysis.

Results

The results of multivariate analysis show that hypertension (odds ratio [OR], 1.51; 95% confidence interval [CI], 1.05–2.18) and smoking (odds ratio [OR], 1.57; 95% confidence interval [CI], 1.06–2.33) were independent risk factors for rupture of intracranial aneurysms. The joint risk of hypertension and smoking was higher (OR, 2.28; 95% CI, 1.29–4.02) than the risks of hypertension (OR, 1.74; 95% CI, 1.11–2.72) and smoking (OR, 1.86; 95% CI, 1.05–3.29) independently.

Conclusions

Hypertension and smoking increase of the rupture risk of intracranial aneurysms. And the joint risk of hypertension and smoking was higher than the risks of hypertension and smoking independently.

Abstract

Background

In general population, the prevalence of intracranial aneurysm reaches as high as three percent. The goal of the study was to analyze retrospectively the independent risk factors for the rupture of intracranial aneurysms and their joint effect.

Methods

The records and angiographies of continuous 519 intracranial aneurysm patients treated at our center between February 2013 and July 2014 were retrospectively analyzed. Ruptured group and unruptured group were included in the study according to their clinical and imaging information. Univariate analysis and multivariate logistic regression analysis was used to identified independent risk factors for the rupture of intracranial aneurysms. We assessed the joint effect of independent risk factors for the rupture of intracranial aneurysms with an additional logistic regression analysis.

Results

The results of multivariate analysis show that hypertension (odds ratio [OR], 1.51; 95% confidence interval [CI], 1.05–2.18) and smoking (odds ratio [OR], 1.57; 95% confidence interval [CI], 1.06–2.33) were independent risk factors for rupture of intracranial aneurysms. The joint risk of hypertension and smoking was higher (OR, 2.28; 95% CI, 1.29–4.02) than the risks of hypertension (OR, 1.74; 95% CI, 1.11–2.72) and smoking (OR, 1.86; 95% CI, 1.05–3.29) independently.

Conclusions

Hypertension and smoking increase of the rupture risk of intracranial aneurysms. And the joint risk of hypertension and smoking was higher than the risks of hypertension and smoking independently.

Get Citation

Keywords

Intracranial aneurysms, Hypertension, Smoking, Rupture, Risk factors

About this article
Title

Impact of hypertension and smoking on the rupture of intracranial aneurysms and their joint effect

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 49, No 2 (2015)

Pages

121-125

DOI

10.1016/j.pjnns.2015.03.005

Bibliographic record

Neurol Neurochir Pol 2015;49(2):121-125.

Keywords

Intracranial aneurysms
Hypertension
Smoking
Rupture
Risk factors

Authors

Huibin Kang
Tangming Peng
Zenghui Qian
Youxiang Li
Chuhan Jiang
Wenjun Ji
Jing Wu
Wenjuan Xu
Xiaolong Wen
Aihua Liu

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