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Impact of hypertension and smoking on the rupture of intracranial aneurysms and their joint effect
Affiliations- Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, China
- Department of Nephrology, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Dongcheng District, Beijing 100050, China,, beijing, China
- Department of Neurosurgery, The Affiliated Hospital of Luzhou Medical College, China
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Abstract
In general population, the prevalence of intracranial aneurysm reaches as high as three percent. The goal of the study was to analyze retrospectively the independent risk factors for the rupture of intracranial aneurysms and their joint effect.
MethodsThe records and angiographies of continuous 519 intracranial aneurysm patients treated at our center between February 2013 and July 2014 were retrospectively analyzed. Ruptured group and unruptured group were included in the study according to their clinical and imaging information. Univariate analysis and multivariate logistic regression analysis was used to identified independent risk factors for the rupture of intracranial aneurysms. We assessed the joint effect of independent risk factors for the rupture of intracranial aneurysms with an additional logistic regression analysis.
ResultsThe results of multivariate analysis show that hypertension (odds ratio [OR], 1.51; 95% confidence interval [CI], 1.05–2.18) and smoking (odds ratio [OR], 1.57; 95% confidence interval [CI], 1.06–2.33) were independent risk factors for rupture of intracranial aneurysms. The joint risk of hypertension and smoking was higher (OR, 2.28; 95% CI, 1.29–4.02) than the risks of hypertension (OR, 1.74; 95% CI, 1.11–2.72) and smoking (OR, 1.86; 95% CI, 1.05–3.29) independently.
ConclusionsHypertension and smoking increase of the rupture risk of intracranial aneurysms. And the joint risk of hypertension and smoking was higher than the risks of hypertension and smoking independently.
Abstract
In general population, the prevalence of intracranial aneurysm reaches as high as three percent. The goal of the study was to analyze retrospectively the independent risk factors for the rupture of intracranial aneurysms and their joint effect.
MethodsThe records and angiographies of continuous 519 intracranial aneurysm patients treated at our center between February 2013 and July 2014 were retrospectively analyzed. Ruptured group and unruptured group were included in the study according to their clinical and imaging information. Univariate analysis and multivariate logistic regression analysis was used to identified independent risk factors for the rupture of intracranial aneurysms. We assessed the joint effect of independent risk factors for the rupture of intracranial aneurysms with an additional logistic regression analysis.
ResultsThe results of multivariate analysis show that hypertension (odds ratio [OR], 1.51; 95% confidence interval [CI], 1.05–2.18) and smoking (odds ratio [OR], 1.57; 95% confidence interval [CI], 1.06–2.33) were independent risk factors for rupture of intracranial aneurysms. The joint risk of hypertension and smoking was higher (OR, 2.28; 95% CI, 1.29–4.02) than the risks of hypertension (OR, 1.74; 95% CI, 1.11–2.72) and smoking (OR, 1.86; 95% CI, 1.05–3.29) independently.
ConclusionsHypertension and smoking increase of the rupture risk of intracranial aneurysms. And the joint risk of hypertension and smoking was higher than the risks of hypertension and smoking independently.
Keywords
Intracranial aneurysms, Hypertension, Smoking, Rupture, Risk factors
About this articleTitle
Impact of hypertension and smoking on the rupture of intracranial aneurysms and their joint effect
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
121-125
Page views
290
Article views/downloads
375
DOI
10.1016/j.pjnns.2015.03.005
Bibliographic record
Neurol Neurochir Pol 2015;49(2):121-125.
Keywords
Intracranial aneurysms
Hypertension
Smoking
Rupture
Risk factors
Authors
Huibin Kang
Tangming Peng
Zenghui Qian
Youxiang Li
Chuhan Jiang
Wenjun Ji
Jing Wu
Wenjuan Xu
Xiaolong Wen
Aihua Liu
