open access

Vol 49, No 1 (2015)
Case reports
Submitted: 2014-01-09
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Melatonin and cortisol profiles in patients with pituitary tumors

Daniel Zielonka, Jerzy Sowiński, Stanisław Nowak, Anna Ciesielska, Jakub Moskal, Jerzy T. Marcinkowski
DOI: 10.1016/j.pjnns.2014.12.004
·
Neurol Neurochir Pol 2015;49(1):65-69.

open access

Vol 49, No 1 (2015)
Case reports
Submitted: 2014-01-09

Abstract

The optic tract section at the optic chiasm is expected to disturb the suprachiasmatic nucleus (SCN) rhythm, circadian rhythm and melatonin secretion rhythms in humans, although detailed studies have never been conducted. The aim of this paper was to describe melatonin and cortisol profiles in patients with a pituitary tumor exerting optic chiasm compression. Six patients with pituitary tumors of different size, four of whom had significant optic chiasm compression, were examined. In each brain, MRI, an ophthalmological examination including the vision field and laboratory tests were performed. Melatonin and cortisol concentrations were measured at 22:00h, 02:00h, 06:00h, and 10:00h in patients lying in a dark, isolated room.

One of the four cases with significant optic chiasm compression presented a flattened melatonin rhythm. The melatonin rhythm was also disturbed in one patient without optic chiasm compression. Larger tumors may play a role in the destruction of neurons connecting the retina with the suprachiasmatic nucleus (SCN) and breaking of basic way for inhibiting effect to the SCN from the retina.

Abstract

The optic tract section at the optic chiasm is expected to disturb the suprachiasmatic nucleus (SCN) rhythm, circadian rhythm and melatonin secretion rhythms in humans, although detailed studies have never been conducted. The aim of this paper was to describe melatonin and cortisol profiles in patients with a pituitary tumor exerting optic chiasm compression. Six patients with pituitary tumors of different size, four of whom had significant optic chiasm compression, were examined. In each brain, MRI, an ophthalmological examination including the vision field and laboratory tests were performed. Melatonin and cortisol concentrations were measured at 22:00h, 02:00h, 06:00h, and 10:00h in patients lying in a dark, isolated room.

One of the four cases with significant optic chiasm compression presented a flattened melatonin rhythm. The melatonin rhythm was also disturbed in one patient without optic chiasm compression. Larger tumors may play a role in the destruction of neurons connecting the retina with the suprachiasmatic nucleus (SCN) and breaking of basic way for inhibiting effect to the SCN from the retina.

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Keywords

Melatonin, Cortisol, Pituitary tumors, Biological rhythm

About this article
Title

Melatonin and cortisol profiles in patients with pituitary tumors

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 49, No 1 (2015)

Pages

65-69

DOI

10.1016/j.pjnns.2014.12.004

Bibliographic record

Neurol Neurochir Pol 2015;49(1):65-69.

Keywords

Melatonin
Cortisol
Pituitary tumors
Biological rhythm

Authors

Daniel Zielonka
Jerzy Sowiński
Stanisław Nowak
Anna Ciesielska
Jakub Moskal
Jerzy T. Marcinkowski

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