open access

Vol 48, No 6 (2014)
Original research articles
Submitted: 2014-09-09
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TNFα gene G-308A polymorphism and the risk of ischemic stroke

Alicja Wawrzynek, Jacek Dobiała, Mieczysław Wender, Wojciech Kozubski, Grażyna Michałowska-Wender
DOI: 10.1016/j.pjnns.2014.09.007
·
Neurol Neurochir Pol 2014;48(6):387-390.

open access

Vol 48, No 6 (2014)
Original research articles
Submitted: 2014-09-09

Abstract

TNFα, a significant immune mediator, may contribute to the initiation and progression of the ischemic stroke. Genetics of TNFα molecule may have an important role in the risk of ischemic stroke. The most interesting aspects of the G-308A polymorphism remain unexplained; there are many discrepancies between the results. Differences in the ethnicity of the studied cohorts may be taken as one of the possibility. Our study material consisted of 101 patients with ischemic stroke, including 30% classified as lacunar stroke. The diagnosis was based on the presence of rapidly developing neurological signs lasting longer then 24h and confirmed by neuroimaging matter. All patients were of Polish Caucasian origin. Randomly selected 100 individuals without any sign of the vascular disease of central nervous system were taken as the control material. The frequency of polymorphism G-308A in TNFα gene was determined as described by Rubattu et al. [11]. The genotype distribution in our material was similar and statistically insignificant between patients and controls. The heterozygotic G/A genotype was detected in 9% of patients and in 15% of control materials, homozygotic A/A was found in 5% of patients and only in one of control and G/G in 87% of patients and in 84% of control individuals. Our results are negative with respect to the impact of 308 TNFα polymorphism on the risk of ischemic stroke in Caucasians living in Poland.

Abstract

TNFα, a significant immune mediator, may contribute to the initiation and progression of the ischemic stroke. Genetics of TNFα molecule may have an important role in the risk of ischemic stroke. The most interesting aspects of the G-308A polymorphism remain unexplained; there are many discrepancies between the results. Differences in the ethnicity of the studied cohorts may be taken as one of the possibility. Our study material consisted of 101 patients with ischemic stroke, including 30% classified as lacunar stroke. The diagnosis was based on the presence of rapidly developing neurological signs lasting longer then 24h and confirmed by neuroimaging matter. All patients were of Polish Caucasian origin. Randomly selected 100 individuals without any sign of the vascular disease of central nervous system were taken as the control material. The frequency of polymorphism G-308A in TNFα gene was determined as described by Rubattu et al. [11]. The genotype distribution in our material was similar and statistically insignificant between patients and controls. The heterozygotic G/A genotype was detected in 9% of patients and in 15% of control materials, homozygotic A/A was found in 5% of patients and only in one of control and G/G in 87% of patients and in 84% of control individuals. Our results are negative with respect to the impact of 308 TNFα polymorphism on the risk of ischemic stroke in Caucasians living in Poland.

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Keywords

Polymorphism, TNFα, Ischemic stroke

About this article
Title

TNFα gene G-308A polymorphism and the risk of ischemic stroke

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 48, No 6 (2014)

Pages

387-390

DOI

10.1016/j.pjnns.2014.09.007

Bibliographic record

Neurol Neurochir Pol 2014;48(6):387-390.

Keywords

Polymorphism
TNFα
Ischemic stroke

Authors

Alicja Wawrzynek
Jacek Dobiała
Mieczysław Wender
Wojciech Kozubski
Grażyna Michałowska-Wender

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