open access

Vol 48, No 3 (2014)
Case reports
Submitted: 2014-03-06
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Symptomatic copper deficiency in three Wilson's disease patients treated with zinc sulphate

Karolina Dzieżyc, Tomasz Litwin, Anna Sobańska, Anna Członkowska
DOI: 10.1016/j.pjnns.2014.05.002
·
Neurol Neurochir Pol 2014;48(3):214-218.

open access

Vol 48, No 3 (2014)
Case reports
Submitted: 2014-03-06

Abstract

Wilson's disease (WD) is caused by excess of copper that leads to accumulation of copper mainly in the liver, brain and needs life-long decoppering therapy. However, overtreatment with anti-copper agents may lead to copper deficiency which may cause neurological and hematological symptoms. Copper is an important cofactor for many enzymes. This report describes three WD patients with diagnosed copper deficiency during zinc sulphate (ZS) treatment. After 5–16 years of therapy all patients developed leucopenia. Spinal cord injury was manifested in two of the patients. One of them also presented myopathy. In conclusion, copper deficiency may occur in different time after treatment onset, therefore regular copper metabolism and hematological monitoring is necessary.

Abstract

Wilson's disease (WD) is caused by excess of copper that leads to accumulation of copper mainly in the liver, brain and needs life-long decoppering therapy. However, overtreatment with anti-copper agents may lead to copper deficiency which may cause neurological and hematological symptoms. Copper is an important cofactor for many enzymes. This report describes three WD patients with diagnosed copper deficiency during zinc sulphate (ZS) treatment. After 5–16 years of therapy all patients developed leucopenia. Spinal cord injury was manifested in two of the patients. One of them also presented myopathy. In conclusion, copper deficiency may occur in different time after treatment onset, therefore regular copper metabolism and hematological monitoring is necessary.

Get Citation

Keywords

Copper deficiency, Wilson' s disease, Zinc sulphate

About this article
Title

Symptomatic copper deficiency in three Wilson's disease patients treated with zinc sulphate

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 48, No 3 (2014)

Pages

214-218

DOI

10.1016/j.pjnns.2014.05.002

Bibliographic record

Neurol Neurochir Pol 2014;48(3):214-218.

Keywords

Copper deficiency
Wilson's disease
Zinc sulphate

Authors

Karolina Dzieżyc
Tomasz Litwin
Anna Sobańska
Anna Członkowska

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