Vol 48, No 3 (2014)

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Symptomatic copper deficiency in three Wilson's disease patients treated with zinc sulphate

Karolina Dzieżyc1, Tomasz Litwin1, Anna Sobańska2, Anna Członkowska13
DOI: 10.1016/j.pjnns.2014.05.002
Neurol Neurochir Pol 2014;48(3):214-218.


Wilson's disease (WD) is caused by excess of copper that leads to accumulation of copper mainly in the liver, brain and needs life-long decoppering therapy. However, overtreatment with anti-copper agents may lead to copper deficiency which may cause neurological and hematological symptoms. Copper is an important cofactor for many enzymes. This report describes three WD patients with diagnosed copper deficiency during zinc sulphate (ZS) treatment. After 5–16 years of therapy all patients developed leucopenia. Spinal cord injury was manifested in two of the patients. One of them also presented myopathy. In conclusion, copper deficiency may occur in different time after treatment onset, therefore regular copper metabolism and hematological monitoring is necessary.

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Neurologia i Neurochirurgia Polska