open access

Vol 48, No 2 (2014)
Review article
Submitted: 2012-08-14
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Alternating hemiplegia of childhood: New diagnostic options

Aleksandra Gergont, Marek Kaciński
DOI: 10.1016/j.pjnns.2013.05.003
·
Neurol Neurochir Pol 2014;48(2):130-135.

open access

Vol 48, No 2 (2014)
Review article
Submitted: 2012-08-14

Abstract

A syndrome of alternating hemiplegia of childhood (AHC) is a rare disorder first presented in 1971. AHC is characterized by transient episodes of hemiplegia affecting either one or both sides of the body. Age of onset is before 18 months and the common earliest manifestations are dystonic or tonic attacks and nystagmus. Hemiplegic episodes last minutes to days and the frequency and duration tend to decrease with time. Motor and intellectual development is affected, deficits may also develop later. Epileptic seizures occur in some patients. Neuroimaging of the brain usually reveals no abnormalities. The variability of individual clinical presentations and evolution of symptoms have made diagnosis difficult. Therefore the problems of misdiagnosis could account for the low prevalence of this syndrome. This paper hopes to present actual data on AHC, especially of the results of genetic research and new diagnostic tools.

Abstract

A syndrome of alternating hemiplegia of childhood (AHC) is a rare disorder first presented in 1971. AHC is characterized by transient episodes of hemiplegia affecting either one or both sides of the body. Age of onset is before 18 months and the common earliest manifestations are dystonic or tonic attacks and nystagmus. Hemiplegic episodes last minutes to days and the frequency and duration tend to decrease with time. Motor and intellectual development is affected, deficits may also develop later. Epileptic seizures occur in some patients. Neuroimaging of the brain usually reveals no abnormalities. The variability of individual clinical presentations and evolution of symptoms have made diagnosis difficult. Therefore the problems of misdiagnosis could account for the low prevalence of this syndrome. This paper hopes to present actual data on AHC, especially of the results of genetic research and new diagnostic tools.

Get Citation

Keywords

Alternating hemiplegia, Children, ATP1A3

About this article
Title

Alternating hemiplegia of childhood: New diagnostic options

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 48, No 2 (2014)

Pages

130-135

DOI

10.1016/j.pjnns.2013.05.003

Bibliographic record

Neurol Neurochir Pol 2014;48(2):130-135.

Keywords

Alternating hemiplegia
Children
ATP1A3

Authors

Aleksandra Gergont
Marek Kaciński

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