open access

Vol 48, No 2 (2014)
Original research articles
Submitted: 2013-04-24
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The FGA Thr312Ala polymorphism and risk of intracerebral haemorrhage in Polish and Greek populations

Jeremiasz Jagiełła, Efthimios Dardiotis, Jerzy Gąsowski, Joanna Pera, Tomasz Dziedzic, Aleksandra Klimkowicz-Mrowiec, Aleksandra Golenia, Marcin Wnuk, Kostas Fountas, Konstantinos Paterakis, Georgios Hadjigeorgiou, Agnieszka Słowik
DOI: 10.1016/j.pjnns.2013.12.004
·
Neurol Neurochir Pol 2014;48(2):105-110.

open access

Vol 48, No 2 (2014)
Original research articles
Submitted: 2013-04-24

Abstract

Background and purpose

Spontaneous intracerebral haemorrhage (ICH) is the most fatal form of stroke with the highest morbidity and disability rate of all stroke types. Recent data suggest that the genetic background has a sizeable and mostly undiscovered effect on the brain haemorrhage risk. Since the coagulation system is crucial to ICH pathology, we studied the significance of the FGA Thr312Ala polymorphism in two European populations.

Materials and methods

We genotyped 550 and 224 controls as well as 261 and 242 stroke patients in Polish and Greek populations, respectively. The ICH diagnosis was confirmed by computed tomography. The FGA Thr312Ala polymorphism was analysed using real-time polymorphism chain reaction.

Results

Both crude and multivariable regression analyses showed that the studied polymorphism is a protective factor in the Polish population under the dominant and additive models of inheritance. Those results did not replicate in the Greek population. The meta-analysis of results from the Polish and the Greek populations proved that FGA Thr312Ala polymorphism affects the risk of ICH in the dominant model of inheritance.

Conclusions

The FGA Thr312Ala polymorphism affects a risk for ICH in the Polish but not in the Greek population. An advanced meta-analysis of well-designed studies with a significant number of cases might provide useful information of novel polymorphisms, including the FGA Thr312Ala polymorphism, and their role in ICH pathology.

Abstract

Background and purpose

Spontaneous intracerebral haemorrhage (ICH) is the most fatal form of stroke with the highest morbidity and disability rate of all stroke types. Recent data suggest that the genetic background has a sizeable and mostly undiscovered effect on the brain haemorrhage risk. Since the coagulation system is crucial to ICH pathology, we studied the significance of the FGA Thr312Ala polymorphism in two European populations.

Materials and methods

We genotyped 550 and 224 controls as well as 261 and 242 stroke patients in Polish and Greek populations, respectively. The ICH diagnosis was confirmed by computed tomography. The FGA Thr312Ala polymorphism was analysed using real-time polymorphism chain reaction.

Results

Both crude and multivariable regression analyses showed that the studied polymorphism is a protective factor in the Polish population under the dominant and additive models of inheritance. Those results did not replicate in the Greek population. The meta-analysis of results from the Polish and the Greek populations proved that FGA Thr312Ala polymorphism affects the risk of ICH in the dominant model of inheritance.

Conclusions

The FGA Thr312Ala polymorphism affects a risk for ICH in the Polish but not in the Greek population. An advanced meta-analysis of well-designed studies with a significant number of cases might provide useful information of novel polymorphisms, including the FGA Thr312Ala polymorphism, and their role in ICH pathology.

Get Citation

Keywords

Intracerebral haemorrhage, Brain haemorrhage, Haemorrhagic stroke, FGA Thr312Ala

About this article
Title

The FGA Thr312Ala polymorphism and risk of intracerebral haemorrhage in Polish and Greek populations

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 48, No 2 (2014)

Pages

105-110

DOI

10.1016/j.pjnns.2013.12.004

Bibliographic record

Neurol Neurochir Pol 2014;48(2):105-110.

Keywords

Intracerebral haemorrhage
Brain haemorrhage
Haemorrhagic stroke
FGA Thr312Ala

Authors

Jeremiasz Jagiełła
Efthimios Dardiotis
Jerzy Gąsowski
Joanna Pera
Tomasz Dziedzic
Aleksandra Klimkowicz-Mrowiec
Aleksandra Golenia
Marcin Wnuk
Kostas Fountas
Konstantinos Paterakis
Georgios Hadjigeorgiou
Agnieszka Słowik

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