open access

Vol 48, No 1 (2014)
Original research articles
Submitted: 2013-01-03
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Circle of Willis abnormalities in children with neurofibromatosis type 1

Monika Bekiesińska-Figatowska, Hanna Brągoszewska, Marek Duczkowski, Anna Romaniuk-Doroszewska, Sylwia Szkudlińska-Pawlak, Agnieszka Duczkowska, Jarosław Mądzik, Barbara Kowalska, Paweł Pęczkowski
DOI: 10.1016/j.pjnns.2013.05.002
·
Neurol Neurochir Pol 2014;48(1):15-20.

open access

Vol 48, No 1 (2014)
Original research articles
Submitted: 2013-01-03

Abstract

Background and purpose

The aim of the study was to assess anatomical variants and abnormalities in cerebral arteries on magnetic resonance angiography in 67 children with neurofibromatosis type 1 (NF1).

Materials and methods

The study included 67 children aged 9 months to 18 years (mean 6.6 years). Control group comprised 90 children aged 2–18 years (mean: 11.8 years). All patients were examined at 1.5T scanner.

Results

We found cerebral arteriopathy (moyamoya disease) in one child (1.5%) in the study group. No aneurysms were found. Twenty-nine NF1 children (43.3%) had arterial anatomical variants. In 13 of them, more than one variant was diagnosed (44.8% of group with variants, 19.4% of study group). In control group, 19 children (21.1%) had variants, including four children with more than one variant (21% of group with variants, 4.4% of control group). Arterial variants were more common in NF1 patients compared with control group (p=0.026, binomial test for two proportions). Percentage of multiple variants was higher in study group than in control group, but this difference was not significant. Variants were more frequent on left side than on the right one (significant difference in control group; p=0.022, McNemara test). In study group, the number of left-sided anomalies (25) was similar to that of right-sided ones (22). There was no correlation between gender and variants, unidentified bright objects and variants or between optic gliomas and variants.

Conclusions

Occurrence of arterial variants in NF1 patients was twofold higher than in control group. Multiple variants were more frequent in the study group although the difference did not reach statistical significance. Features of cerebral arteriopathy were found in one child with NF1.

Abstract

Background and purpose

The aim of the study was to assess anatomical variants and abnormalities in cerebral arteries on magnetic resonance angiography in 67 children with neurofibromatosis type 1 (NF1).

Materials and methods

The study included 67 children aged 9 months to 18 years (mean 6.6 years). Control group comprised 90 children aged 2–18 years (mean: 11.8 years). All patients were examined at 1.5T scanner.

Results

We found cerebral arteriopathy (moyamoya disease) in one child (1.5%) in the study group. No aneurysms were found. Twenty-nine NF1 children (43.3%) had arterial anatomical variants. In 13 of them, more than one variant was diagnosed (44.8% of group with variants, 19.4% of study group). In control group, 19 children (21.1%) had variants, including four children with more than one variant (21% of group with variants, 4.4% of control group). Arterial variants were more common in NF1 patients compared with control group (p=0.026, binomial test for two proportions). Percentage of multiple variants was higher in study group than in control group, but this difference was not significant. Variants were more frequent on left side than on the right one (significant difference in control group; p=0.022, McNemara test). In study group, the number of left-sided anomalies (25) was similar to that of right-sided ones (22). There was no correlation between gender and variants, unidentified bright objects and variants or between optic gliomas and variants.

Conclusions

Occurrence of arterial variants in NF1 patients was twofold higher than in control group. Multiple variants were more frequent in the study group although the difference did not reach statistical significance. Features of cerebral arteriopathy were found in one child with NF1.

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Keywords

Neurofibromatosis type 1, Magnetic resonance angiography, Brain, Arteriopathy, Arterial variants

About this article
Title

Circle of Willis abnormalities in children with neurofibromatosis type 1

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 48, No 1 (2014)

Pages

15-20

DOI

10.1016/j.pjnns.2013.05.002

Bibliographic record

Neurol Neurochir Pol 2014;48(1):15-20.

Keywords

Neurofibromatosis type 1
Magnetic resonance angiography
Brain
Arteriopathy
Arterial variants

Authors

Monika Bekiesińska-Figatowska
Hanna Brągoszewska
Marek Duczkowski
Anna Romaniuk-Doroszewska
Sylwia Szkudlińska-Pawlak
Agnieszka Duczkowska
Jarosław Mądzik
Barbara Kowalska
Paweł Pęczkowski

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