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Pharmacotherapy prior to and in acute ischaemic stroke. The use of pharmacotherapy and drugs-associated outcomes in real-world practice – findings from the Polish Hospital Stroke Registry
- Katedra i Zakład Farmakologii Doświadczalnej i Klinicznej, Warszawski Uniwersytet Medyczny
- II Klinika Neurologiczna, Instytut Psychiatrii i Neurologii w Warszawie
- Zakład Wspomagania i Analizy Decyzji, Instytut Ekonometrii, Szkota Główna Handlowa w Warszawie
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Abstract
Stroke is a preventable disease and acute ischaemic stroke can be effectively treated. Specific pharmacotherapy is recommended in either prevention or acute ischemic stroke treatment. We aimed to evaluate the use and the early and late outcomes impact of drugs administered before and in acute ischaemic stroke in a real world practice.
Material and methodsIschaemic stroke patients hospitalized between 1st March 2007 and 29th February 2008 and reported in Polish Hospital Stroke Registry were analysed. Fully anonymous data were collected with standardized, web-based questionnaire with authorized access. Multivariate regression models were used to adjust for case-mix and evaluate the impact of drugs used prior to or in acute ischaemic stroke on outcomes. The early outcomes were defined as in-hospital mortality or poor outcome (death or dependency – modified Rankin Scale ≥ 3) at hospital discharge, while late outcomes covered one-year survival.
ResultsA total number of 26 153 ischaemic stroke patients (mean age: 71.8 years; females: 51.6%) was reported. The analysis of pharmacotherapy showed that preventive use of hypotensive agents, anticoagulants in atrial fibrillation, antiplatelets and statins is inadequate. Regression models confirmed some expected drug benefits and additionally revealed that antihypertensive drugs or aspirin used prior to stroke and oral anticoagulants or statins used in hospital were associated with better stroke outcome.
ConclusionsThe prevention of ischaemic stroke needs to be monitored and improved. Evidence-based treatment of acute ischaemic stroke requires further promotion. The benefits of acute ischaemic stroke treatment with statins require to be confirmed in randomized controlled settings.
Abstract
Stroke is a preventable disease and acute ischaemic stroke can be effectively treated. Specific pharmacotherapy is recommended in either prevention or acute ischemic stroke treatment. We aimed to evaluate the use and the early and late outcomes impact of drugs administered before and in acute ischaemic stroke in a real world practice.
Material and methodsIschaemic stroke patients hospitalized between 1st March 2007 and 29th February 2008 and reported in Polish Hospital Stroke Registry were analysed. Fully anonymous data were collected with standardized, web-based questionnaire with authorized access. Multivariate regression models were used to adjust for case-mix and evaluate the impact of drugs used prior to or in acute ischaemic stroke on outcomes. The early outcomes were defined as in-hospital mortality or poor outcome (death or dependency – modified Rankin Scale ≥ 3) at hospital discharge, while late outcomes covered one-year survival.
ResultsA total number of 26 153 ischaemic stroke patients (mean age: 71.8 years; females: 51.6%) was reported. The analysis of pharmacotherapy showed that preventive use of hypotensive agents, anticoagulants in atrial fibrillation, antiplatelets and statins is inadequate. Regression models confirmed some expected drug benefits and additionally revealed that antihypertensive drugs or aspirin used prior to stroke and oral anticoagulants or statins used in hospital were associated with better stroke outcome.
ConclusionsThe prevention of ischaemic stroke needs to be monitored and improved. Evidence-based treatment of acute ischaemic stroke requires further promotion. The benefits of acute ischaemic stroke treatment with statins require to be confirmed in randomized controlled settings.
Keywords
ischaemic stroke, pharmacotherapy aspirin, oral anticoagulants, antihypertensives, statins
Title
Pharmacotherapy prior to and in acute ischaemic stroke. The use of pharmacotherapy and drugs-associated outcomes in real-world practice – findings from the Polish Hospital Stroke Registry
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
509-516
Page views
419
Article views/downloads
290
DOI
10.5114/ninp.2013.39067
Bibliographic record
Neurol Neurochir Pol 2013;47(6):509-516.
Keywords
ischaemic stroke
pharmacotherapy aspirin
oral anticoagulants
antihypertensives
statins
Authors
Maciej Niewada
Iwona Marta Sarzyńska-Długosz
Marta Skowrońska
Bogumił Kamiński
Adam Kobayashi
Anna Członkowska