open access

Vol 47, No 5 (2013)
ARTYKUŁ ORYGINALNY
Submitted: 2012-10-11
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The influence of the menstrual cycle on the result of brain examination with hydrogen magnetic resonance spectroscopy – a pilot study

Robert Chrzan, Monika Tomaszuk, Andrzej Urbanik
DOI: 10.5114/ninp.2013.38224
·
Neurol Neurochir Pol 2013;47(5):450-455.

open access

Vol 47, No 5 (2013)
ARTYKUŁ ORYGINALNY
Submitted: 2012-10-11

Abstract

Background and purpose

Hydrogen magnetic resonance spectroscopy (1HMRS) is nowadays one of the basic tools for noninvasive brain metabolism assessment. The study focuses on the important problem of the influence of hormone fluctuation during the menstrual cycle on brain metabolism, assessed by 1HMRS for clinical diagnostics.

Material and methods

In 11 healthy regularly menstruating women, 1HMRS was performed at the start (phase I), in the middle (phase II) and at the end (phase III) of the menstrual cycle. The relative concentration ratios of 12 brain metabolites in every woman in all cycle phases were examined, in 6 different volumes of interest (VOIs). Finally, statistically significant differences in relative metabolite ratios between the phases examined in given locations were sought.

Results

Statistically significant relations between menstrual cycle phases and relative ratios of 4 metabolites – Lac/Cr, NAA/Cr, Glx1/Cr and Glx2/Cr – in different brain locations were found. In all locations, mean NAA/Cr ratios were greater in phase I compared to the other phases. A similar relationship was found for Glx1/Cr ratio in one location (left occipital lobe). For Lac/Cr and Glx2/Cr ratios, a higher mean ratio value was obtained in phase II compared to phases I and III in the right occipital lobe and left basal ganglia, respectively.

Conclusions

Menstrual cycle phase should be considered in planning a date and interpretation of 1HMRS examination, performed for the verification of a disease manifesting as brain metabolite disturbances in the 1HMRS spectrum.

Abstract

Background and purpose

Hydrogen magnetic resonance spectroscopy (1HMRS) is nowadays one of the basic tools for noninvasive brain metabolism assessment. The study focuses on the important problem of the influence of hormone fluctuation during the menstrual cycle on brain metabolism, assessed by 1HMRS for clinical diagnostics.

Material and methods

In 11 healthy regularly menstruating women, 1HMRS was performed at the start (phase I), in the middle (phase II) and at the end (phase III) of the menstrual cycle. The relative concentration ratios of 12 brain metabolites in every woman in all cycle phases were examined, in 6 different volumes of interest (VOIs). Finally, statistically significant differences in relative metabolite ratios between the phases examined in given locations were sought.

Results

Statistically significant relations between menstrual cycle phases and relative ratios of 4 metabolites – Lac/Cr, NAA/Cr, Glx1/Cr and Glx2/Cr – in different brain locations were found. In all locations, mean NAA/Cr ratios were greater in phase I compared to the other phases. A similar relationship was found for Glx1/Cr ratio in one location (left occipital lobe). For Lac/Cr and Glx2/Cr ratios, a higher mean ratio value was obtained in phase II compared to phases I and III in the right occipital lobe and left basal ganglia, respectively.

Conclusions

Menstrual cycle phase should be considered in planning a date and interpretation of 1HMRS examination, performed for the verification of a disease manifesting as brain metabolite disturbances in the 1HMRS spectrum.

Get Citation

Keywords

menstrual cycle, brain metabolism, 1HMRS

About this article
Title

The influence of the menstrual cycle on the result of brain examination with hydrogen magnetic resonance spectroscopy – a pilot study

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 47, No 5 (2013)

Pages

450-455

DOI

10.5114/ninp.2013.38224

Bibliographic record

Neurol Neurochir Pol 2013;47(5):450-455.

Keywords

menstrual cycle
brain metabolism
1HMRS

Authors

Robert Chrzan
Monika Tomaszuk
Andrzej Urbanik

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