open access

Vol 47, No 5 (2013)
ARTYKUŁ ORYGINALNY
Submitted: 2012-06-25
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Magnetic resonance spectroscopy in intracranial tumours of glial origin

Dariusz J. Jaskólski, Jan Fortuniak, Agata Majos, Witold Gajewicz, Wielisław Papierz, Paweł P. Liberski, Beata Sikorska, Ludomir Stefańczyk
DOI: 10.5114/ninp.2013.32999
·
Neurol Neurochir Pol 2013;47(5):438-449.

open access

Vol 47, No 5 (2013)
ARTYKUŁ ORYGINALNY
Submitted: 2012-06-25

Abstract

Background and purpose

To determine in vivo magnetic resonance spectroscopy (MRS) characteristics of intracranial glial tumours and to assess MRS reliability in glioma grading and discrimination between different histopathological types of tumours.

Material and methods

Analysis of spectra of 26 patients with glioblastomas, 6 with fibrillary astrocytomas, 4 with anaplastic astrocytomas, 2 with pilocytic astrocytoma, 3 with oligodendrogliomas, 3 with anaplastic oligodendrogliomas and 17 control spectra taken from healthy hemispheres.

Results

All tumours’ metabolite ratios, except for Cho/Cr in fibrillary astrocytomas (p = 0.06), were statistically signiflcantly different from the control. The tumours showed decreased Naa and Cr contents and a high Cho signal. The Lac-Lip signal was high in grade III astrocytomas and glioblastomas. Reports that Cho/Cr ratio increases with glioma's grade whereas Naa/Cr decreases were not confirmed. Anaplastic astrocytomas compared to grade II astrocytomas had a statistically significantly greater ml/Cr ratio (p = 0.02). In pilocytic astrocytomas the Naa/Cr value (2.58 ± 0.39) was greater, whilst the Cho/Naa ratio was lower (2.14 ± 0.64) than in the other astrocytomas. The specific feature of oligodendrogliomas was the presence of glutamate/glutamine peak Glx. However, this peak was absent in two out of three anaplastic oligodendrogliomas. Characteristically, the latter tumours had a high Lac-Lip signal.

Conclusions

MRS in vivo cannot be used as a reliable method for glioma grading. The method is useful in discrimination between WHO grade I and WHO grade II astrocytomas as well as oligodendrogliomas from other gliomas.

Abstract

Background and purpose

To determine in vivo magnetic resonance spectroscopy (MRS) characteristics of intracranial glial tumours and to assess MRS reliability in glioma grading and discrimination between different histopathological types of tumours.

Material and methods

Analysis of spectra of 26 patients with glioblastomas, 6 with fibrillary astrocytomas, 4 with anaplastic astrocytomas, 2 with pilocytic astrocytoma, 3 with oligodendrogliomas, 3 with anaplastic oligodendrogliomas and 17 control spectra taken from healthy hemispheres.

Results

All tumours’ metabolite ratios, except for Cho/Cr in fibrillary astrocytomas (p = 0.06), were statistically signiflcantly different from the control. The tumours showed decreased Naa and Cr contents and a high Cho signal. The Lac-Lip signal was high in grade III astrocytomas and glioblastomas. Reports that Cho/Cr ratio increases with glioma's grade whereas Naa/Cr decreases were not confirmed. Anaplastic astrocytomas compared to grade II astrocytomas had a statistically significantly greater ml/Cr ratio (p = 0.02). In pilocytic astrocytomas the Naa/Cr value (2.58 ± 0.39) was greater, whilst the Cho/Naa ratio was lower (2.14 ± 0.64) than in the other astrocytomas. The specific feature of oligodendrogliomas was the presence of glutamate/glutamine peak Glx. However, this peak was absent in two out of three anaplastic oligodendrogliomas. Characteristically, the latter tumours had a high Lac-Lip signal.

Conclusions

MRS in vivo cannot be used as a reliable method for glioma grading. The method is useful in discrimination between WHO grade I and WHO grade II astrocytomas as well as oligodendrogliomas from other gliomas.

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Keywords

magnetic resonance spectroscopy, glioblastoma, astrocytoma, oligodendroglioma

About this article
Title

Magnetic resonance spectroscopy in intracranial tumours of glial origin

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 47, No 5 (2013)

Pages

438-449

DOI

10.5114/ninp.2013.32999

Bibliographic record

Neurol Neurochir Pol 2013;47(5):438-449.

Keywords

magnetic resonance spectroscopy
glioblastoma
astrocytoma
oligodendroglioma

Authors

Dariusz J. Jaskólski
Jan Fortuniak
Agata Majos
Witold Gajewicz
Wielisław Papierz
Paweł P. Liberski
Beata Sikorska
Ludomir Stefańczyk

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