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Effect of liver transplantation on brain magnetic resonance imaging pathology in Wilson disease: a case report
Affiliations- Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
- Department of Neuroradiology, Chang Gung Memorial Hospital — Kaohsiung Medical Center and College of Medicine, Chang Gung University, Kaohsiung
- chair and department of experimental and clinical pharmacology, medical university of warsaw
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Abstract
The authors present a case report of a 28-year-old patient with hepatic, but no neurological, signs of Wilson disease, with pathological changes in both the globi pallidi and caudate found with routine brain magnetic resonance imaging (MRI). The patient was recommended for liver transplantation by hepatologists, and during the two years of observation after liver transplantation, MRI brain abnormalities due to Wilson disease completely regressed. On the basis of this case, the authors present an argument for the prognostic significance of brain MRI in Wilson disease as well as current recommendations concerning liver transplantation in Wilson disease.
Abstract
The authors present a case report of a 28-year-old patient with hepatic, but no neurological, signs of Wilson disease, with pathological changes in both the globi pallidi and caudate found with routine brain magnetic resonance imaging (MRI). The patient was recommended for liver transplantation by hepatologists, and during the two years of observation after liver transplantation, MRI brain abnormalities due to Wilson disease completely regressed. On the basis of this case, the authors present an argument for the prognostic significance of brain MRI in Wilson disease as well as current recommendations concerning liver transplantation in Wilson disease.
Keywords
Wilson disease, liver transplantation, copper metabolism
About this articleTitle
Effect of liver transplantation on brain magnetic resonance imaging pathology in Wilson disease: a case report
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
393-397
Page views
217
Article views/downloads
342
DOI
10.5114/ninp.2013.36763
Bibliographic record
Neurol Neurochir Pol 2013;47(4):393-397.
Keywords
Wilson disease
liver transplantation
copper metabolism
Authors
Tomasz Litwin
Karolina Dzieżyc
Renata Poniatowska
Anna Członkowska
