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CD4+CD28− lymphocytes and ischaemic stroke. Part I: CD4+CD28− lymphocytes and common carotid artery intima-media thickness
Affiliations- II Klinika Neurologii, Instytut Psychiatrii i Neurologii w Warszawie
- Katedra Biochemii i Chemii Medycznej, Pomorski Uniwersytet Medyczny w Szczecinie
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Abstract
More and more data point to the involvement of the CD4+CD28− lymphocyte subpopulation in the pathogenesis of ischaemic stroke. This paper attempts to answer the question of whether an increase in the percentage of CD4+CD28− lymphocytes in the blood may be associated with carotid artery intima-media thickness (IMT).
Material and methodsThe study involved a group of 109 patients, aged 45 to 65 years, including 42 patients with first-ever ischaemic stroke, experiencing symptoms resulting from disturbances of the anterior area of cerebral circulation, arterial hypertension and/or type 2 diabetes mellitus (group 1). Group 2 consisted of 34 patients with above-mentioned risk factors but without ischaemic stroke. The control group comprised 33 healthy individuals. Distribution of sex and mean age was comparable. The IMT of carotid arteries was measured by ultrasonography. Flow cytometry was applied to determine the percentage of CD4+CD28− lymphocytes in the peripheral blood.
ResultsThe IMT was significantly greater in patients with stroke than in patients without stroke. No significant correlation was found between the proportion of CD4+CD28− lymphocytes in the blood and the IMT of carotid arteries.
ConclusionsThe significant proportion of CD4+CD28− lymphocytes in patients with ischaemic stroke points to the involvement of the cells in the pathogenesis of stroke. The CD4+CD28− lymphocytes are not involved in the pathomechanism of common carotid arteries IMT thickening in this group of patients.
Abstract
More and more data point to the involvement of the CD4+CD28− lymphocyte subpopulation in the pathogenesis of ischaemic stroke. This paper attempts to answer the question of whether an increase in the percentage of CD4+CD28− lymphocytes in the blood may be associated with carotid artery intima-media thickness (IMT).
Material and methodsThe study involved a group of 109 patients, aged 45 to 65 years, including 42 patients with first-ever ischaemic stroke, experiencing symptoms resulting from disturbances of the anterior area of cerebral circulation, arterial hypertension and/or type 2 diabetes mellitus (group 1). Group 2 consisted of 34 patients with above-mentioned risk factors but without ischaemic stroke. The control group comprised 33 healthy individuals. Distribution of sex and mean age was comparable. The IMT of carotid arteries was measured by ultrasonography. Flow cytometry was applied to determine the percentage of CD4+CD28− lymphocytes in the peripheral blood.
ResultsThe IMT was significantly greater in patients with stroke than in patients without stroke. No significant correlation was found between the proportion of CD4+CD28− lymphocytes in the blood and the IMT of carotid arteries.
ConclusionsThe significant proportion of CD4+CD28− lymphocytes in patients with ischaemic stroke points to the involvement of the cells in the pathogenesis of stroke. The CD4+CD28− lymphocytes are not involved in the pathomechanism of common carotid arteries IMT thickening in this group of patients.
Keywords
ischaemic stroke, intima-media thickness, common carotid artery, ultrasonography, CD4+CD28− lymphocytes
About this articleTitle
CD4+CD28− lymphocytes and ischaemic stroke. Part I: CD4+CD28− lymphocytes and common carotid artery intima-media thickness
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
201-207
Page views
284
Article views/downloads
271
DOI
10.5114/ninp.2013.35573
Bibliographic record
Neurol Neurochir Pol 2013;47(3):201-207.
Keywords
ischaemic stroke
intima-media thickness
common carotid artery
ultrasonography
CD4+CD28− lymphocytes
Authors
Hanna Drechsler
Marta Masztalewicz
Krzysztof Safranow
Przemysław Nowacki
