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A case of a solitary form of Castleman disease: ten-year follow-up
Affiliations- department of neurosurgery
- Department of Medical Pathomorphology, Medical University of Białystok, Białystok, Poland
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Abstract
Castleman disease (CD) is a rare atypical lymphoproliferative process of obscure pathogenesis. An intracranial localization of the condition is extremely rare. We present a case of a 29-year-old man, who harbored an intracranial plasma cell variant of CD in the form of a tumor mimicking meningioma and was followed up to 10 years after surgical excision of the lesion. The histopathological examination showed massive infiltration of mononuclear cells, composed mainly of lymphocytes and matured plasmocytes, as well as many small thin-walled vessels surrounded with plasma cells and lymphocytes. This picture was consistent with a plasma cell type of CD. Ten-year follow-up supports a notion that total surgical excision of the solitary intracranial infiltration is curative in plasma cell type of CD.
Abstract
Castleman disease (CD) is a rare atypical lymphoproliferative process of obscure pathogenesis. An intracranial localization of the condition is extremely rare. We present a case of a 29-year-old man, who harbored an intracranial plasma cell variant of CD in the form of a tumor mimicking meningioma and was followed up to 10 years after surgical excision of the lesion. The histopathological examination showed massive infiltration of mononuclear cells, composed mainly of lymphocytes and matured plasmocytes, as well as many small thin-walled vessels surrounded with plasma cells and lymphocytes. This picture was consistent with a plasma cell type of CD. Ten-year follow-up supports a notion that total surgical excision of the solitary intracranial infiltration is curative in plasma cell type of CD.
Keywords
Castleman disease, meningioma-like lesion, surgical treatment
About this articleTitle
A case of a solitary form of Castleman disease: ten-year follow-up
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
179-183
Page views
346
Article views/downloads
552
DOI
10.5114/ninp.2013.34636
Bibliographic record
Neurol Neurochir Pol 2013;47(2):179-183.
Keywords
Castleman disease
meningioma-like lesion
surgical treatment
Authors
Grzegorz Turek
Joanna Reszeć
Jan Kochanowicz
Adam Hermanowicz
Zenon Mariak
