open access

Vol 47, No 2 (2013)
Krótkie doniesienie
Submitted: 2012-03-17
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Lack of association of CR1, PICALM and CLU gene polymorphisms with Alzheimer disease in a Polish population

Aleksandra Klimkowicz-Mrowiec, Małgorzata Sado, Anna Dziubek, Tomasz Dziedzic, Joanna Pera, Andrzej Szczudlik, Agnieszka Słowik
DOI: 10.5114/ninp.2013.33825
·
Neurol Neurochir Pol 2013;47(2):157-160.

open access

Vol 47, No 2 (2013)
Krótkie doniesienie
Submitted: 2012-03-17

Abstract

Background and purpose

Recent genome-wide association studies have indicated 3 new susceptibility loci for Alzheimer disease (AD): complement receptor 1 (CR1), clusterin (CLU), and the phosphatidylinositol-binding clathrin assembly protein (PICALM). We investigated the influence of the rs6656401 single nucleotide polymorphisms (SNP) of the CR1 gene, the rs3851179 SNP of the PICALM gene, and the rs11136000 SNP of the CLU gene on risk of AD in a Polish population.

Material and methods

In 253 Caucasian AD patients and 240 controls, analyses identifying the rs6656401, rs3851179 and rs11136000 SNPs and APOE common polymorphisms were performed.

Results

No significant differences were observed in the distribution of the rs6656401 of CR1, rs3851179 of PICALM and rs11136000 of CLU SNPs between AD patients and controls. The APOE ɛ4 common polymorphism was strongly related to the risk of AD.

Conclusion

Our results suggest that investigated SNPs are not associated with AD in a Polish population.

Abstract

Background and purpose

Recent genome-wide association studies have indicated 3 new susceptibility loci for Alzheimer disease (AD): complement receptor 1 (CR1), clusterin (CLU), and the phosphatidylinositol-binding clathrin assembly protein (PICALM). We investigated the influence of the rs6656401 single nucleotide polymorphisms (SNP) of the CR1 gene, the rs3851179 SNP of the PICALM gene, and the rs11136000 SNP of the CLU gene on risk of AD in a Polish population.

Material and methods

In 253 Caucasian AD patients and 240 controls, analyses identifying the rs6656401, rs3851179 and rs11136000 SNPs and APOE common polymorphisms were performed.

Results

No significant differences were observed in the distribution of the rs6656401 of CR1, rs3851179 of PICALM and rs11136000 of CLU SNPs between AD patients and controls. The APOE ɛ4 common polymorphism was strongly related to the risk of AD.

Conclusion

Our results suggest that investigated SNPs are not associated with AD in a Polish population.

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Keywords

Alzheimer disease, CR1, PICALM, CLU, single nucleotide polymorphism

About this article
Title

Lack of association of CR1, PICALM and CLU gene polymorphisms with Alzheimer disease in a Polish population

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 47, No 2 (2013)

Pages

157-160

DOI

10.5114/ninp.2013.33825

Bibliographic record

Neurol Neurochir Pol 2013;47(2):157-160.

Keywords

Alzheimer disease
CR1
PICALM
CLU
single nucleotide polymorphism

Authors

Aleksandra Klimkowicz-Mrowiec
Małgorzata Sado
Anna Dziubek
Tomasz Dziedzic
Joanna Pera
Andrzej Szczudlik
Agnieszka Słowik

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