open access

Vol 47, No 2 (2013)
ARTYKUŁ ORYGINALNY
Submitted: 2012-06-09
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The β-fibrinogen –455G/A gene polymorphism and the risk of ischaemic stroke in a Polish population

Aleksandra Golenia, Joanna Chrzanowska-Wasko, Jeremiasz Jagiella, Marcin Wnuk, Antoni Ferens, Aleksandra Klimkowicz-Mrowiec, Mateusz Adamski, Irena Ciecko-Michalska, Agnieszka Słowik
DOI: 10.5114/ninp.2013.34462
·
Neurol Neurochir Pol 2013;47(2):152-156.

open access

Vol 47, No 2 (2013)
ARTYKUŁ ORYGINALNY
Submitted: 2012-06-09

Abstract

Background and purpose

Ischaemic stroke is considered to be multifactorial and interactions between environmental and genetic factors play an important role. Although vascular risk factors are well known, the genetic ones are still undiscovered. In the present study, we assessed the significance of the β-fibrinogen –455G/A gene polymorphism and the risk of ischaemic stroke in a Polish population.

Material and methods

426 ischaemic stroke patients classified according to stroke aetiologies (small vessel disease, large vessel disease or cardioembolic stroke) and 234 controls were included in the study. The association of the β-fibrinogen genotypes with ischaemic stroke was tested using logistic regression analysis under dominant, recessive or additive models of inheritance.

Results

The allele and genotype distributions of the β-fibrinogen –455G/A gene polymorphism did not differ significantly between patients and controls (patients: G – 75%, GG – 56.6%, GA – 36.8%, AA – 6.6%; controls: G – 73.7%, GG – 57.3%, GA – 32.9%, AA – 9.8%; p > 0.05, χ2). In addition, logistic regression analysis adjusted for the known risk factors, i.e. hypertension, ischaemic heart disease, myocardial infarction, hypercholesterolaemia, diabetes mellitus and smoking, did not show a role of the studied polymorphism in ischaemic stroke.

Conclusions

The β-fibrinogen –455G/A gene polymorphism is not a risk factor for ischaemic stroke in a Polish population.

Abstract

Background and purpose

Ischaemic stroke is considered to be multifactorial and interactions between environmental and genetic factors play an important role. Although vascular risk factors are well known, the genetic ones are still undiscovered. In the present study, we assessed the significance of the β-fibrinogen –455G/A gene polymorphism and the risk of ischaemic stroke in a Polish population.

Material and methods

426 ischaemic stroke patients classified according to stroke aetiologies (small vessel disease, large vessel disease or cardioembolic stroke) and 234 controls were included in the study. The association of the β-fibrinogen genotypes with ischaemic stroke was tested using logistic regression analysis under dominant, recessive or additive models of inheritance.

Results

The allele and genotype distributions of the β-fibrinogen –455G/A gene polymorphism did not differ significantly between patients and controls (patients: G – 75%, GG – 56.6%, GA – 36.8%, AA – 6.6%; controls: G – 73.7%, GG – 57.3%, GA – 32.9%, AA – 9.8%; p > 0.05, χ2). In addition, logistic regression analysis adjusted for the known risk factors, i.e. hypertension, ischaemic heart disease, myocardial infarction, hypercholesterolaemia, diabetes mellitus and smoking, did not show a role of the studied polymorphism in ischaemic stroke.

Conclusions

The β-fibrinogen –455G/A gene polymorphism is not a risk factor for ischaemic stroke in a Polish population.

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Keywords

ischaemic stroke, fibrinogen, single nucleotide polymorphism

About this article
Title

The β-fibrinogen –455G/A gene polymorphism and the risk of ischaemic stroke in a Polish population

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 47, No 2 (2013)

Pages

152-156

DOI

10.5114/ninp.2013.34462

Bibliographic record

Neurol Neurochir Pol 2013;47(2):152-156.

Keywords

ischaemic stroke
fibrinogen
single nucleotide polymorphism

Authors

Aleksandra Golenia
Joanna Chrzanowska-Wasko
Jeremiasz Jagiella
Marcin Wnuk
Antoni Ferens
Aleksandra Klimkowicz-Mrowiec
Mateusz Adamski
Irena Ciecko-Michalska
Agnieszka Słowik

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