open access

Vol 47, No 1 (2013)
ARTYKUŁ ORYGINALNY
Submitted: 2012-08-22
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Polymorphisms of paraoxonase 1 and 2 genes and the risk of multiple sclerosis in the Polish population

Beata Zakrzewska-Pniewska, Monika Nojszewska, Teresa Róg, Jarosław Pniewski, Małgorzata Dorobek, Maria Styczyńska, Andrzej Szczudlik
DOI: 10.5114/ninp.2013.32935
·
Neurol Neurochir Pol 2013;47(1):49-52.

open access

Vol 47, No 1 (2013)
ARTYKUŁ ORYGINALNY
Submitted: 2012-08-22

Abstract

Background and purpose

The aim of this study was to test the hypothesis that polymorphisms of the paraoxonase genes PON1 and PON2 may be associated with increased risk of developing multiple sclerosis (MS) in the Polish population.

Material and methods

We studied the significance of the PON gene polymorphisms C311S, A162G, Q192R and L55M in 221 patients (including 145 women) with MS and in 661 healthy controls. In the MS population, mean Expanded Disability Status Scale score was 2.92, mean age was 36.8 years, and mean disease duration was 7.7 years. PON genotyping was determined using polymerase chain reaction and restriction enzyme digestion.

Results

According to our results, the PON1 and PON2 genotypes distribution did not differ between the MS patients and the controls.

Conclusions

The polymorphisms of the PON genes studied are not related to increased risk of MS in the Polish population.

Abstract

Background and purpose

The aim of this study was to test the hypothesis that polymorphisms of the paraoxonase genes PON1 and PON2 may be associated with increased risk of developing multiple sclerosis (MS) in the Polish population.

Material and methods

We studied the significance of the PON gene polymorphisms C311S, A162G, Q192R and L55M in 221 patients (including 145 women) with MS and in 661 healthy controls. In the MS population, mean Expanded Disability Status Scale score was 2.92, mean age was 36.8 years, and mean disease duration was 7.7 years. PON genotyping was determined using polymerase chain reaction and restriction enzyme digestion.

Results

According to our results, the PON1 and PON2 genotypes distribution did not differ between the MS patients and the controls.

Conclusions

The polymorphisms of the PON genes studied are not related to increased risk of MS in the Polish population.

Get Citation

Keywords

multiple sclerosis, PON1, PON2, polymorphism

About this article
Title

Polymorphisms of paraoxonase 1 and 2 genes and the risk of multiple sclerosis in the Polish population

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 47, No 1 (2013)

Pages

49-52

DOI

10.5114/ninp.2013.32935

Bibliographic record

Neurol Neurochir Pol 2013;47(1):49-52.

Keywords

multiple sclerosis
PON1
PON2
polymorphism

Authors

Beata Zakrzewska-Pniewska
Monika Nojszewska
Teresa Róg
Jarosław Pniewski
Małgorzata Dorobek
Maria Styczyńska
Andrzej Szczudlik

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