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Polymorphisms of paraoxonase 1 and 2 genes and the risk of multiple sclerosis in the Polish population
Affiliations- Katedra i Klinika Neurologii w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach
- Katedra i Klinika Neurologii Collegium Medicum, Uniwersytet Jagielloński w Krakowie
- KIinika Neurologii, Szpital Czerniakowski w Warszawie
- II Klinika Neurologii, Instytut Psychiatrii i Neurologii w Warszawie
- Zespół Badawczo-Leczniczy Chorób Zwyrodnieniowych CUN, Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN w Warszawie
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Abstract
The aim of this study was to test the hypothesis that polymorphisms of the paraoxonase genes PON1 and PON2 may be associated with increased risk of developing multiple sclerosis (MS) in the Polish population.
Material and methodsWe studied the significance of the PON gene polymorphisms C311S, A162G, Q192R and L55M in 221 patients (including 145 women) with MS and in 661 healthy controls. In the MS population, mean Expanded Disability Status Scale score was 2.92, mean age was 36.8 years, and mean disease duration was 7.7 years. PON genotyping was determined using polymerase chain reaction and restriction enzyme digestion.
ResultsAccording to our results, the PON1 and PON2 genotypes distribution did not differ between the MS patients and the controls.
ConclusionsThe polymorphisms of the PON genes studied are not related to increased risk of MS in the Polish population.
Abstract
The aim of this study was to test the hypothesis that polymorphisms of the paraoxonase genes PON1 and PON2 may be associated with increased risk of developing multiple sclerosis (MS) in the Polish population.
Material and methodsWe studied the significance of the PON gene polymorphisms C311S, A162G, Q192R and L55M in 221 patients (including 145 women) with MS and in 661 healthy controls. In the MS population, mean Expanded Disability Status Scale score was 2.92, mean age was 36.8 years, and mean disease duration was 7.7 years. PON genotyping was determined using polymerase chain reaction and restriction enzyme digestion.
ResultsAccording to our results, the PON1 and PON2 genotypes distribution did not differ between the MS patients and the controls.
ConclusionsThe polymorphisms of the PON genes studied are not related to increased risk of MS in the Polish population.
Keywords
multiple sclerosis, PON1, PON2, polymorphism
About this articleTitle
Polymorphisms of paraoxonase 1 and 2 genes and the risk of multiple sclerosis in the Polish population
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
49-52
Page views
262
Article views/downloads
355
DOI
10.5114/ninp.2013.32935
Bibliographic record
Neurol Neurochir Pol 2013;47(1):49-52.
Keywords
multiple sclerosis
PON1
PON2
polymorphism
Authors
Beata Zakrzewska-Pniewska
Monika Nojszewska
Teresa Róg
Jarosław Pniewski
Małgorzata Dorobek
Maria Styczyńska
Andrzej Szczudlik
