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Cerebral vasoreactivity in hypocapnia and hypercapnia in patients with diabetes mellitus type 2 with or without arterial hypertension
Affiliations- Katedra i Klinika Neurologii w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach
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Abstract
Diabetes mellitus (DM) is an independent risk factor for cardiovascular diseases. The origin of diabetic microangiopathy is multifactorial; it affects all layers of the artery wall, causing endothelial and vasoreactivity impairment. The incidence of cerebral vasoreactivity failure in diabetic patients without stroke history is not precisely determined yet. The aim of the study was to assess the cerebrovascular reactivity in hypocapnia and hypercapnia in patients with type 2 DM with or without arterial hypertension without artery stenosis and stroke history, with the use of transcranial Doppler examination.
Material and methodsThe mean blood flow velocity, pulsatility index and parameters of cerebrovascular reactivity were measured in 53 patients with type 2 DM (aged 42–72 years, mean 59.5 ± 7.9) and in 27 healthy volunteers (aged 36–74 years, mean 57.0 ± 10.4). Diabetics were further divided into two subgroups according to the presence or absence of arterial hypertension.
ResultsThe index of cerebrovascular reactivity in hypocapnia and hypercapnia was significantly worse and time needed to normalization of blood flow velocity was significantly longer in patients with DM in comparison with healthy volunteers.
ConclusionsMost DM type 2 patients without stroke history had decreased values of cerebral vasoreactivity parameters, which suggests the presence of microangiopathy.
Abstract
Diabetes mellitus (DM) is an independent risk factor for cardiovascular diseases. The origin of diabetic microangiopathy is multifactorial; it affects all layers of the artery wall, causing endothelial and vasoreactivity impairment. The incidence of cerebral vasoreactivity failure in diabetic patients without stroke history is not precisely determined yet. The aim of the study was to assess the cerebrovascular reactivity in hypocapnia and hypercapnia in patients with type 2 DM with or without arterial hypertension without artery stenosis and stroke history, with the use of transcranial Doppler examination.
Material and methodsThe mean blood flow velocity, pulsatility index and parameters of cerebrovascular reactivity were measured in 53 patients with type 2 DM (aged 42–72 years, mean 59.5 ± 7.9) and in 27 healthy volunteers (aged 36–74 years, mean 57.0 ± 10.4). Diabetics were further divided into two subgroups according to the presence or absence of arterial hypertension.
ResultsThe index of cerebrovascular reactivity in hypocapnia and hypercapnia was significantly worse and time needed to normalization of blood flow velocity was significantly longer in patients with DM in comparison with healthy volunteers.
ConclusionsMost DM type 2 patients without stroke history had decreased values of cerebral vasoreactivity parameters, which suggests the presence of microangiopathy.
Keywords
cerebral vasoreactivity, diabetes mellitus, hypocapnia, hypercapnia
About this articleTitle
Cerebral vasoreactivity in hypocapnia and hypercapnia in patients with diabetes mellitus type 2 with or without arterial hypertension
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
529-535
Page views
328
Article views/downloads
588
DOI
10.5114/ninp.2012.32175
Bibliographic record
Neurol Neurochir Pol 2012;46(6):529-535.
Keywords
cerebral vasoreactivity
diabetes mellitus
hypocapnia
hypercapnia
Authors
Anetta Lasek-Bal
Zofia Kazibutowska
Anna Gołba
Ewa Motta
