open access

Vol 46, No 5 (2012)
ARTYKUŁ POGLĄDOWY
Submitted: 2011-09-07
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Diffusion tensor imaging in Alzheimer disease and mild cognitive impairment

Irena Štěpán-Buksakowska, Jiří Keller, Jan Laczó, Aaron Rulseh, Jakub Hort, Jiří Lisý, František Charvát, Miloslav Roček, Daniel Hořínek
DOI: 10.5114/ninp.2012.31357
·
Neurol Neurochir Pol 2012;46(5):462-471.

open access

Vol 46, No 5 (2012)
ARTYKUŁ POGLĄDOWY
Submitted: 2011-09-07

Abstract

A wide range of imaging studies provides growing support for the potential role of diffusion tensor imaging (DTI) in evaluating microstructural white matter integrity in Alzheimer disease (AD) and mild cognitive impairment (MCI). Our review aims to present DTI principles, post-processing and analysis frameworks and to report the results of particular studies.

The distribution of AD-related white matter abnormalities is widely discussed in the light of deteriorated connectivity within certain tracts due to secondary white matter degeneration; primary alterations are also assumed to contribute to the pattern. The question whether it is more effective to assess the whole-brain diffusion or to directly concentrate on specific regions remains an interesting issue. Assessing white matter microstructure alterations, as evaluated by group-level differences of tensor-derived parameters, may be a promising neuroimaging tool for differential diagnosis between AD, MCI and other cognitive disorders, as well as being particularly helpful in the interpretation of underlying pathological processes.

Abstract

A wide range of imaging studies provides growing support for the potential role of diffusion tensor imaging (DTI) in evaluating microstructural white matter integrity in Alzheimer disease (AD) and mild cognitive impairment (MCI). Our review aims to present DTI principles, post-processing and analysis frameworks and to report the results of particular studies.

The distribution of AD-related white matter abnormalities is widely discussed in the light of deteriorated connectivity within certain tracts due to secondary white matter degeneration; primary alterations are also assumed to contribute to the pattern. The question whether it is more effective to assess the whole-brain diffusion or to directly concentrate on specific regions remains an interesting issue. Assessing white matter microstructure alterations, as evaluated by group-level differences of tensor-derived parameters, may be a promising neuroimaging tool for differential diagnosis between AD, MCI and other cognitive disorders, as well as being particularly helpful in the interpretation of underlying pathological processes.

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Keywords

Alzheimer disease, diffusion tensor imaging, mild cognitive impairment

About this article
Title

Diffusion tensor imaging in Alzheimer disease and mild cognitive impairment

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 46, No 5 (2012)

Pages

462-471

DOI

10.5114/ninp.2012.31357

Bibliographic record

Neurol Neurochir Pol 2012;46(5):462-471.

Keywords

Alzheimer disease
diffusion tensor imaging
mild cognitive impairment

Authors

Irena Štěpán-Buksakowska
Jiří Keller
Jan Laczó
Aaron Rulseh
Jakub Hort
Jiří Lisý
František Charvát
Miloslav Roček
Daniel Hořínek

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