open access

Vol 46, No 5 (2012)
ARTYKUŁ ORYGINALNY
Submitted: 2011-11-26
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Serum S100B protein: a useful marker in obstructive sleep apnea syndrome

Serap Duru, Ibrahim Hikmet Firat, Nujen Colak, Zeynep Giniş, Tuncay Delibaşi, Sadik Ardiç
DOI: 10.5114/ninp.2012.31355
·
Neurol Neurochir Pol 2012;46(5):450-455.

open access

Vol 46, No 5 (2012)
ARTYKUŁ ORYGINALNY
Submitted: 2011-11-26

Abstract

Background and purpose

We aimed to underline the importance of serum S100B protein as a useful biochemical marker in patients with obstructive sleep apnea syndrome (OSAS).

Material and methods

Forty-three newly diagnosed patients with OSAS (median apnea-hypopnea index [AHI, events/hour]: 37.5 [range 11.3–137]) and 25 subjects with AHI < 5 (median AHI: 4.4 [range 0.7–4.8]) were included in the study. Serum S100B protein level was tested in serum samples taken after polysomnography in both groups and the difference between OSAS patients and the control group regarding that level was assessed. In addition, the association of S100B protein serum level with age, body mass index, AHI, mean O2 saturation percentage during sleep, minimum O2 saturation value (%) at the end of the apneas, and the time spent at an O2 saturation less than 90% were analyzed in the OSAS patient group.

Results

Median serum S100B protein level was 133.7 pg/mL (range 20.97–230.70 pg/mL) in patients with OSAS and 16.1 pg/mL (range 10.1–22.9 pg/mL) in the control group (p < 0.005). Serum S100B protein level did not correlate with any studied variable (p > 0.05 for each correlation coefficient).

Conclusions

Serum S100B protein level is increased in patients with OSAS and may be a useful biochemical marker in those patients.

Abstract

Background and purpose

We aimed to underline the importance of serum S100B protein as a useful biochemical marker in patients with obstructive sleep apnea syndrome (OSAS).

Material and methods

Forty-three newly diagnosed patients with OSAS (median apnea-hypopnea index [AHI, events/hour]: 37.5 [range 11.3–137]) and 25 subjects with AHI < 5 (median AHI: 4.4 [range 0.7–4.8]) were included in the study. Serum S100B protein level was tested in serum samples taken after polysomnography in both groups and the difference between OSAS patients and the control group regarding that level was assessed. In addition, the association of S100B protein serum level with age, body mass index, AHI, mean O2 saturation percentage during sleep, minimum O2 saturation value (%) at the end of the apneas, and the time spent at an O2 saturation less than 90% were analyzed in the OSAS patient group.

Results

Median serum S100B protein level was 133.7 pg/mL (range 20.97–230.70 pg/mL) in patients with OSAS and 16.1 pg/mL (range 10.1–22.9 pg/mL) in the control group (p < 0.005). Serum S100B protein level did not correlate with any studied variable (p > 0.05 for each correlation coefficient).

Conclusions

Serum S100B protein level is increased in patients with OSAS and may be a useful biochemical marker in those patients.

Get Citation

Keywords

S100B protein, obstructive sleep apnea syndrome, marker

About this article
Title

Serum S100B protein: a useful marker in obstructive sleep apnea syndrome

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 46, No 5 (2012)

Pages

450-455

DOI

10.5114/ninp.2012.31355

Bibliographic record

Neurol Neurochir Pol 2012;46(5):450-455.

Keywords

S100B protein
obstructive sleep apnea syndrome
marker

Authors

Serap Duru
Ibrahim Hikmet Firat
Nujen Colak
Zeynep Giniş
Tuncay Delibaşi
Sadik Ardiç

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