open access

Vol 46, No 2 (2012)
ARTYKUŁ ORYGINALNY
Submitted: 2011-09-24
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A single-fibre electromyography study of neuromuscular transmission in patients with cluster headache

Izabela Domitrz, Małgorzata Gaweł, Wojciech Domitrz, Anna Kostera-Pruszczyk, Hubert Kwieciński
DOI: 10.5114/ninp.2012.28256
·
Neurol Neurochir Pol 2012;46(2):140-144.

open access

Vol 46, No 2 (2012)
ARTYKUŁ ORYGINALNY
Submitted: 2011-09-24

Abstract

Background and purpose

Mutations of CACNA1A, which encodes a neuronal P/Q Ca2+ channel, are present in patients with familial hemiplegic migraine, and possibly in other types of migraine as well. This calcium channel is also involved in neuromuscular transmission. In our previous study we confirmed that the single-fibre electromyography (SFEMG) method can demonstrate a neuromuscular transmission deficit in migraine with aura. The aim of our present study was to estimate the neurotransmitter dysfunction in cluster headache and to compare the results between patients with cluster headache and those with migraine with aura.

Material and methods

We selected 6 patients with cluster headache and 6 patients with migraine with typical aura. SFEMG of the voluntarily activated extensor digitorum communis muscle was performed.

Results

The SFEMG results were in the normal range in the cluster headache group and in the healthy controls. Slight neuromuscular transmission disturbances were present in patients with migraine with aura.

Conclusions

The abnormal neuromuscular transmission detectable by SFEMG may reflect a genetically determined dysfunction of the P/Q Ca2+ channels in a group of migraineurs with aura. Conversely, absence of neuromuscular abnormalities in cluster headache patients could be explained by different aetiology not resulting in channelopathy. Single-fibre electromyography could be a helpful tool in clinically questionable cases in differentiating between cluster headache and migraine with aura.

Abstract

Background and purpose

Mutations of CACNA1A, which encodes a neuronal P/Q Ca2+ channel, are present in patients with familial hemiplegic migraine, and possibly in other types of migraine as well. This calcium channel is also involved in neuromuscular transmission. In our previous study we confirmed that the single-fibre electromyography (SFEMG) method can demonstrate a neuromuscular transmission deficit in migraine with aura. The aim of our present study was to estimate the neurotransmitter dysfunction in cluster headache and to compare the results between patients with cluster headache and those with migraine with aura.

Material and methods

We selected 6 patients with cluster headache and 6 patients with migraine with typical aura. SFEMG of the voluntarily activated extensor digitorum communis muscle was performed.

Results

The SFEMG results were in the normal range in the cluster headache group and in the healthy controls. Slight neuromuscular transmission disturbances were present in patients with migraine with aura.

Conclusions

The abnormal neuromuscular transmission detectable by SFEMG may reflect a genetically determined dysfunction of the P/Q Ca2+ channels in a group of migraineurs with aura. Conversely, absence of neuromuscular abnormalities in cluster headache patients could be explained by different aetiology not resulting in channelopathy. Single-fibre electromyography could be a helpful tool in clinically questionable cases in differentiating between cluster headache and migraine with aura.

Get Citation

Keywords

cluster headache, migraine with aura, P/Q Ca2+ channels, single-fibre electromyography, neuromuscular transmission

About this article
Title

A single-fibre electromyography study of neuromuscular transmission in patients with cluster headache

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 46, No 2 (2012)

Pages

140-144

DOI

10.5114/ninp.2012.28256

Bibliographic record

Neurol Neurochir Pol 2012;46(2):140-144.

Keywords

cluster headache
migraine with aura
P/Q Ca2+ channels
single-fibre electromyography
neuromuscular transmission

Authors

Izabela Domitrz
Małgorzata Gaweł
Wojciech Domitrz
Anna Kostera-Pruszczyk
Hubert Kwieciński

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