open access

Vol 45, No 6 (2011)
ARTYKUŁ ORYGINALNY
Submitted: 2010-08-13
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Sex hormone patterns in women with multiple sclerosis as related to disease activity — a pilot study

Beata Zakrzewska-Pniewska, Marek Gołębiowski, Małgorzata Zajda, Wojciech Szeszkowski, Aleksandra Podlecka-Piętowska, Monika Nojszewska
DOI: 10.1016/S0028-3843(14)60120-1
·
Neurol Neurochir Pol 2011;45(6):536-542.

open access

Vol 45, No 6 (2011)
ARTYKUŁ ORYGINALNY
Submitted: 2010-08-13

Abstract

Background and purpose

The influence of sex hormones on immune system activity in multiple sclerosis (MS) has been suggested by clinical evidence. The aim of the study was to analyse the pattern of sex hormones in MS women and to correlate the hormone pattern abnormalities to the disease course as well as to the magnetic resonance imaging (MRI) results.

Material and methods

We studied the serum level of the progesterone, β-oestradiol and prolactin in 46 women with clinical definite MS aged from 19 to 65; mean disease duration was 11.80 ± 9.86 years. The evaluation of the intensity of hormonal changes was done using a scoring system (0–3). On the brain MRI, the presence of brain atrophy, of hypothalamic demyelination as well as demyelination intensity (or degree) were analysed. The evaluation of the degree of demyelination and brain atrophy was done using a scoring system (0–4).

Results

The main hormonal abnormalities consisted of decreased progesterone level, increased oestradiol level or both. The sex hormone pattern was abnormal in 56% of patients. Hypothalamic lesions were found on MRI in 53% of cases. The abnormal hormonal pattern correlated with intensity of MR changes (p < 0.05, Fisher's exact test), but neither with presence of hypothalamic changes nor with disease parameters (Expanded Disability Status Scale, relapse rate, disease duration).

Conclusions

It is important to check the hormonal pattern in MS women because according to our results it may be related to the disease activity and probably affects the type of therapeutic intervention. This pilot study will be extended in a larger population.

Abstract

Background and purpose

The influence of sex hormones on immune system activity in multiple sclerosis (MS) has been suggested by clinical evidence. The aim of the study was to analyse the pattern of sex hormones in MS women and to correlate the hormone pattern abnormalities to the disease course as well as to the magnetic resonance imaging (MRI) results.

Material and methods

We studied the serum level of the progesterone, β-oestradiol and prolactin in 46 women with clinical definite MS aged from 19 to 65; mean disease duration was 11.80 ± 9.86 years. The evaluation of the intensity of hormonal changes was done using a scoring system (0–3). On the brain MRI, the presence of brain atrophy, of hypothalamic demyelination as well as demyelination intensity (or degree) were analysed. The evaluation of the degree of demyelination and brain atrophy was done using a scoring system (0–4).

Results

The main hormonal abnormalities consisted of decreased progesterone level, increased oestradiol level or both. The sex hormone pattern was abnormal in 56% of patients. Hypothalamic lesions were found on MRI in 53% of cases. The abnormal hormonal pattern correlated with intensity of MR changes (p < 0.05, Fisher's exact test), but neither with presence of hypothalamic changes nor with disease parameters (Expanded Disability Status Scale, relapse rate, disease duration).

Conclusions

It is important to check the hormonal pattern in MS women because according to our results it may be related to the disease activity and probably affects the type of therapeutic intervention. This pilot study will be extended in a larger population.

Get Citation

Keywords

sex hormones, MRI, multiple sclerosis

About this article
Title

Sex hormone patterns in women with multiple sclerosis as related to disease activity — a pilot study

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 45, No 6 (2011)

Pages

536-542

DOI

10.1016/S0028-3843(14)60120-1

Bibliographic record

Neurol Neurochir Pol 2011;45(6):536-542.

Keywords

sex hormones
MRI
multiple sclerosis

Authors

Beata Zakrzewska-Pniewska
Marek Gołębiowski
Małgorzata Zajda
Wojciech Szeszkowski
Aleksandra Podlecka-Piętowska
Monika Nojszewska

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