Vol 45, No 5 (2011)

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The double immunostaining of CD133 and Ki-67 favours a significant co-localization pattern in fibroblastic subtype of meningiomas

Baki S. Albayrak1, Ozgur Ismailoglu1, Gamze Tanriover2, Eralp N. Cetinalp1, Necdet Demir2
DOI: 10.1016/S0028-3843(14)60315-7
Neurol Neurochir Pol 2011;45(5):467-473.


Background and purpose

A unique molecular and/or cellular marker for meningiomas, the most common intracranial tumours, has not been identified yet.

Material and methods

We investigated the co-localization fraction of CD133/Ki-67 in meningioma tissue array slide composed of 80 meningioma tissue samples of various histological variants. CD133 – a cell membrane stem cell marker – was previously proved to be associated with the initiation and progression of intracerebral gliomas and medulloblastomas.


Immunohistochemical co-localization of CD133/Ki-67 was significantly higher in fibroblastic variant than in meningothelial and transitional subtypes. However, since there were only 3 atypical and 1 malignant meningioma spots in the tumour tissue array slide, it is difficult to draw a firm conclusion regarding the actual co-localization percentage and persistence of CD133/Ki-67 in atypical and malignant meningiomas.


Far higher co-staining percentage of CD133/Ki-67 in fibroblastic meningioma samples compared to meningothelial subtype, a histological meningioma variant, architectonically resembling the non-neoplastic meningeal cells, gave us the impression that CD133 may play a role in the formation and progression of fibroblastic meningioma variants. The persistency and the validity of this finding need to be verified by further histopathological and molecular research in order to clarify the possible role of CD133 in meningiogenesis.

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Neurologia i Neurochirurgia Polska