open access

Vol 45, No 4 (2011)
ARTYKUŁ POGLĄDOWY
Submitted: 2010-09-01
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Pleomorphic xanthoastrocytoma – a clinico-pathological review

Aman Sharma, Daya Nand Sharma, Parmod Kumar Julka, Goura Kishor Rath
DOI: 10.1016/S0028-3843(14)60109-2
·
Neurol Neurochir Pol 2011;45(4):379-386.

open access

Vol 45, No 4 (2011)
ARTYKUŁ POGLĄDOWY
Submitted: 2010-09-01

Abstract

Pleomorphic xanthoastrocytoma (PXA) is a rare primary brain tumour which occurs in children and young adults. PXA is designated as low-grade astrocytoma (WHO II), although an anaplastic variant and malignant potential have been described. Pathologically, cellular pleomorphism is the rule and includes spindle cells, mononucleated and multinucleated giant cells, and granular bodies in a reticulin-rich background with few mitoses; necrosis is usually absent. The tumour cells stain positive for glial fibrillary acidic protein (GFAP).

Surgery is the mainstay of treatment with gross surgical resection being accomplished due to its well-circumscribed nature and peripheral location. The role of adjuvant treatment remains yet to be clearly defined. To date, the majority of PXAs have been reported as single or small case series; consequently data of this rare brain tumour are fragmentary. The present paper reviews the pathogenesis, neuroradiological features, prognostic factors and treatment options for PXA.

Abstract

Pleomorphic xanthoastrocytoma (PXA) is a rare primary brain tumour which occurs in children and young adults. PXA is designated as low-grade astrocytoma (WHO II), although an anaplastic variant and malignant potential have been described. Pathologically, cellular pleomorphism is the rule and includes spindle cells, mononucleated and multinucleated giant cells, and granular bodies in a reticulin-rich background with few mitoses; necrosis is usually absent. The tumour cells stain positive for glial fibrillary acidic protein (GFAP).

Surgery is the mainstay of treatment with gross surgical resection being accomplished due to its well-circumscribed nature and peripheral location. The role of adjuvant treatment remains yet to be clearly defined. To date, the majority of PXAs have been reported as single or small case series; consequently data of this rare brain tumour are fragmentary. The present paper reviews the pathogenesis, neuroradiological features, prognostic factors and treatment options for PXA.

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Keywords

brain tumour, pleomorphic xanthoastrocytoma, review

About this article
Title

Pleomorphic xanthoastrocytoma – a clinico-pathological review

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 45, No 4 (2011)

Pages

379-386

DOI

10.1016/S0028-3843(14)60109-2

Bibliographic record

Neurol Neurochir Pol 2011;45(4):379-386.

Keywords

brain tumour
pleomorphic xanthoastrocytoma
review

Authors

Aman Sharma
Daya Nand Sharma
Parmod Kumar Julka
Goura Kishor Rath

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