open access

Vol 45, No 4 (2011)
ARTYKUŁ POGLĄDOWY
Submitted: 2011-02-10
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Dietary treatment of epilepsy: rebirth of an ancient treatment

Sergiusz Jóźwiak, Eric H. Kossoff, Katarzyna Kotulska-Jóźwiak
DOI: 10.1016/S0028-3843(14)60108-0
·
Neurol Neurochir Pol 2011;45(4):370-378.

open access

Vol 45, No 4 (2011)
ARTYKUŁ POGLĄDOWY
Submitted: 2011-02-10

Abstract

Since its introduction in 1921, the ketogenic diet has been in continuous use for children with difficult-to-control epilepsy. After decades of relative disuse, it is now both extremely popular and well studied, with approximately two-thirds of children demonstrating significant seizure reduction after 6 months. It is being used for less intractable seizures in children as well as recently adults. Modifications that help improve tolerability include the medium chain triglyceride diet, modified Atkins diet, and low glycemic index treatment. Major side effects include acidosis, increased cholesterol, kidney stones, gastroesophageal reflux, and growth disturbance. However, these side effects are usually treatable and nowadays often even preventable. Future non-epilepsy indications such as Alzheimer disease, amyotrophic lateral sclerosis, autism, and brain tumors are under active investigation. This dietary treatment for epilepsy has undergone a rebirth. Its widespread use in Poland and Europe is a welcome additional treatment for those with drug-resistant epilepsy.

Abstract

Since its introduction in 1921, the ketogenic diet has been in continuous use for children with difficult-to-control epilepsy. After decades of relative disuse, it is now both extremely popular and well studied, with approximately two-thirds of children demonstrating significant seizure reduction after 6 months. It is being used for less intractable seizures in children as well as recently adults. Modifications that help improve tolerability include the medium chain triglyceride diet, modified Atkins diet, and low glycemic index treatment. Major side effects include acidosis, increased cholesterol, kidney stones, gastroesophageal reflux, and growth disturbance. However, these side effects are usually treatable and nowadays often even preventable. Future non-epilepsy indications such as Alzheimer disease, amyotrophic lateral sclerosis, autism, and brain tumors are under active investigation. This dietary treatment for epilepsy has undergone a rebirth. Its widespread use in Poland and Europe is a welcome additional treatment for those with drug-resistant epilepsy.

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Keywords

ketogenic diet, epilepsy, treatment

About this article
Title

Dietary treatment of epilepsy: rebirth of an ancient treatment

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 45, No 4 (2011)

Pages

370-378

DOI

10.1016/S0028-3843(14)60108-0

Bibliographic record

Neurol Neurochir Pol 2011;45(4):370-378.

Keywords

ketogenic diet
epilepsy
treatment

Authors

Sergiusz Jóźwiak
Eric H. Kossoff
Katarzyna Kotulska-Jóźwiak

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