Vol 45, No 4 (2011)

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Syncope and autonomic cardiovascular dysfunction in Parkinson disease

Marta Leńska-Mieciek1, Ingeborga Derecka-Charzyńska2, Urszula Fiszer1, Leszek Królicki2, Piotr Kułakowski3
DOI: 10.1016/S0028-3843(14)60104-3
Neurol Neurochir Pol 2011;45(4):335-341.


Background and purpose

The aim of the study was to investigate the relationship between syncope or presyncope occurrence and dysfunction of the cardiovascular autonomic system in patients with Parkinson disease (PD).

Material and methods

Twenty-four PD patients were studied, including 10 subjects with syncope/presyncope and 14 controls without those symptoms. Ambulatory blood pressure monitoring (ABPM), Holter electrocardiographic monitoring, carotid sinus massage, tilt test, and cardiac scintigraphy with 123I metaiodobenzylguanidine (MIBG) were performed.


Differences between the two groups were found in myocardial scintigraphy and ABPM. The stepwise regression analyses suggest that the values of late phase reduced uptake of MIBG (95% CI: 0.0–0.77; p < 0.05) and daytime minimum systolic blood pressure (95% CI: 0.78–0.98; p = 0.007) may be related to the occurrence of syncope/presyncope.


The findings suggest an association between syncope/presyncope occurrence and dysfunction of the cardiovascular autonomic system in PD patients. Both 123I MIBG myocardial scintigraphy and ABPM may help identify a group of patients with an elevated risk for syncopic episodes which, in turn, may affect the choice of treatment.

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Neurologia i Neurochirurgia Polska