open access

Vol 45, No 2 (2011)
OPIS PRZYPADKU
Submitted: 2010-03-24
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Lymphocytic hypophysitis: an underestimated disease affecting the sellar region

Bekir Tuğcu, Omur Gunaldi, Lutfi Postalci, Osman Tanriverdi, Ender Ofluoglu, Nurten Sever
DOI: 10.1016/S0028-3843(14)60030-X
·
Neurol Neurochir Pol 2011;45(2):174-179.

open access

Vol 45, No 2 (2011)
OPIS PRZYPADKU
Submitted: 2010-03-24

Abstract

Hypophysitis is an inflammation of the pituitary gland and includes a heterogeneous group of diseases presenting with impaired pituitary gland function. Hundreds of cases have been reported after Goudie and Pinkerton's initial report on a young postpartum woman who died after progressive lymphocytic infiltration of the adenohypophysis in 1962.

A 17-year-old woman presented with a three-year history of headache, galactorrhoea and excessive weight gain. The patient had used oral contraceptives for several years until one year previously. Her examination demonstrated only bilateral heteronymous hemianopsia. Laboratory investigation revealed elevated prolactin and decreased gonadotropin levels. Magnetic resonance imaging showed a sellar mass with suprasellar extension. Surgical removal of the lesion was performed via a transsphenoidal approach. A diagnosis of lymphocytic hypophysitis was confirmed by histopathological evaluation.

Hypophysitis is an underestimated disease affecting the pituitary gland. Cases are usually diagnosed as adenomas and treated with surgical removal. This case is presented due to the extremely rare infiltration of the pituitary gland by predominantly lymphocytes.

Abstract

Hypophysitis is an inflammation of the pituitary gland and includes a heterogeneous group of diseases presenting with impaired pituitary gland function. Hundreds of cases have been reported after Goudie and Pinkerton's initial report on a young postpartum woman who died after progressive lymphocytic infiltration of the adenohypophysis in 1962.

A 17-year-old woman presented with a three-year history of headache, galactorrhoea and excessive weight gain. The patient had used oral contraceptives for several years until one year previously. Her examination demonstrated only bilateral heteronymous hemianopsia. Laboratory investigation revealed elevated prolactin and decreased gonadotropin levels. Magnetic resonance imaging showed a sellar mass with suprasellar extension. Surgical removal of the lesion was performed via a transsphenoidal approach. A diagnosis of lymphocytic hypophysitis was confirmed by histopathological evaluation.

Hypophysitis is an underestimated disease affecting the pituitary gland. Cases are usually diagnosed as adenomas and treated with surgical removal. This case is presented due to the extremely rare infiltration of the pituitary gland by predominantly lymphocytes.

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Keywords

lymphocytic hypophysitis, pituitary adenoma, neuropathology

About this article
Title

Lymphocytic hypophysitis: an underestimated disease affecting the sellar region

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 45, No 2 (2011)

Pages

174-179

DOI

10.1016/S0028-3843(14)60030-X

Bibliographic record

Neurol Neurochir Pol 2011;45(2):174-179.

Keywords

lymphocytic hypophysitis
pituitary adenoma
neuropathology

Authors

Bekir Tuğcu
Omur Gunaldi
Lutfi Postalci
Osman Tanriverdi
Ender Ofluoglu
Nurten Sever

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