Vol 45, No 2 (2011)

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The rs2200733 variant on chromosome 4q25 is a risk factor for cardioembolic stroke related to atrial fibrillation in Polish patients

Marcin Wnuk1, Joanna Pera1, Jeremiasz Jagiełła1, Elżbieta Szczygieł1, Antoni Ferens1, Karolina Spisak1, Paweł Wołkow2, Maria Kmieć1, Jacek Burkot1, Joanna Chrzanowska-Waśko1, Wojciech Turaj1, Agnieszka Słowik1
DOI: 10.1016/S0028-3843(14)60026-8
Neurol Neurochir Pol 2011;45(2):148-151.

Abstract

Background and purpose

A few single nucleotide polymorphisms (SNPs) on chromosome 4q25, associated with atrial fibrillation (AF), are risk factors for ischaemic stroke. We studied the significance of the SNP rs2200733 on chromosome 4q25 in different types of cardioembolic (CE) stroke. Material and methods: We genotyped 428 controls and 301 CE stroke patients, among whom 197 (65.4%) presented with high risk sources of embolism (CE stroke related to AF) and 104 with medium risk sources (CE stroke unrelated to AF). The SNP rs2200733 was analysed using real-time polymorphism chain reaction.

Results

Both univariate and multivariate regression analyses showed that the studied variant affected risk of all CE strokes or CE strokes related to AF in recessive and additive models. The two types of CE stroke differed significantly in demographics and distribution of vascular risk factors.

Conclusions

The SNP rs2200733 on chromosome 4q25 is a risk factor for CE stroke related to AF only.

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Neurologia i Neurochirurgia Polska