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The rs2200733 variant on chromosome 4q25 is a risk factor for cardioembolic stroke related to atrial fibrillation in Polish patients
Affiliations- 1 Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
- Chair and Department of Pharmacology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
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Abstract
A few single nucleotide polymorphisms (SNPs) on chromosome 4q25, associated with atrial fibrillation (AF), are risk factors for ischaemic stroke. We studied the significance of the SNP rs2200733 on chromosome 4q25 in different types of cardioembolic (CE) stroke. Material and methods: We genotyped 428 controls and 301 CE stroke patients, among whom 197 (65.4%) presented with high risk sources of embolism (CE stroke related to AF) and 104 with medium risk sources (CE stroke unrelated to AF). The SNP rs2200733 was analysed using real-time polymorphism chain reaction.
ResultsBoth univariate and multivariate regression analyses showed that the studied variant affected risk of all CE strokes or CE strokes related to AF in recessive and additive models. The two types of CE stroke differed significantly in demographics and distribution of vascular risk factors.
ConclusionsThe SNP rs2200733 on chromosome 4q25 is a risk factor for CE stroke related to AF only.
Abstract
A few single nucleotide polymorphisms (SNPs) on chromosome 4q25, associated with atrial fibrillation (AF), are risk factors for ischaemic stroke. We studied the significance of the SNP rs2200733 on chromosome 4q25 in different types of cardioembolic (CE) stroke. Material and methods: We genotyped 428 controls and 301 CE stroke patients, among whom 197 (65.4%) presented with high risk sources of embolism (CE stroke related to AF) and 104 with medium risk sources (CE stroke unrelated to AF). The SNP rs2200733 was analysed using real-time polymorphism chain reaction.
ResultsBoth univariate and multivariate regression analyses showed that the studied variant affected risk of all CE strokes or CE strokes related to AF in recessive and additive models. The two types of CE stroke differed significantly in demographics and distribution of vascular risk factors.
ConclusionsThe SNP rs2200733 on chromosome 4q25 is a risk factor for CE stroke related to AF only.
Keywords
cardioembolic stroke, atrial fibrillation, polymorphism
About this articleTitle
The rs2200733 variant on chromosome 4q25 is a risk factor for cardioembolic stroke related to atrial fibrillation in Polish patients
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
148-151
Page views
223
Article views/downloads
335
DOI
10.1016/S0028-3843(14)60026-8
Bibliographic record
Neurol Neurochir Pol 2011;45(2):148-151.
Keywords
cardioembolic stroke
atrial fibrillation
polymorphism
Authors
Marcin Wnuk
Joanna Pera
Jeremiasz Jagiełła
Elżbieta Szczygieł
Antoni Ferens
Karolina Spisak
Paweł Wołkow
Maria Kmieć
Jacek Burkot
Joanna Chrzanowska-Waśko
Wojciech Turaj
Agnieszka Słowik
