open access

Vol 45, No 2 (2011)
Krótkie doniesienie
Submitted: 2010-08-25
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The rs2200733 variant on chromosome 4q25 is a risk factor for cardioembolic stroke related to atrial fibrillation in Polish patients

Marcin Wnuk, Joanna Pera, Jeremiasz Jagiełła, Elżbieta Szczygieł, Antoni Ferens, Karolina Spisak, Paweł Wołkow, Maria Kmieć, Jacek Burkot, Joanna Chrzanowska-Waśko, Wojciech Turaj, Agnieszka Słowik
DOI: 10.1016/S0028-3843(14)60026-8
·
Neurol Neurochir Pol 2011;45(2):148-151.

open access

Vol 45, No 2 (2011)
Krótkie doniesienie
Submitted: 2010-08-25

Abstract

Background and purpose

A few single nucleotide polymorphisms (SNPs) on chromosome 4q25, associated with atrial fibrillation (AF), are risk factors for ischaemic stroke. We studied the significance of the SNP rs2200733 on chromosome 4q25 in different types of cardioembolic (CE) stroke. Material and methods: We genotyped 428 controls and 301 CE stroke patients, among whom 197 (65.4%) presented with high risk sources of embolism (CE stroke related to AF) and 104 with medium risk sources (CE stroke unrelated to AF). The SNP rs2200733 was analysed using real-time polymorphism chain reaction.

Results

Both univariate and multivariate regression analyses showed that the studied variant affected risk of all CE strokes or CE strokes related to AF in recessive and additive models. The two types of CE stroke differed significantly in demographics and distribution of vascular risk factors.

Conclusions

The SNP rs2200733 on chromosome 4q25 is a risk factor for CE stroke related to AF only.

Abstract

Background and purpose

A few single nucleotide polymorphisms (SNPs) on chromosome 4q25, associated with atrial fibrillation (AF), are risk factors for ischaemic stroke. We studied the significance of the SNP rs2200733 on chromosome 4q25 in different types of cardioembolic (CE) stroke. Material and methods: We genotyped 428 controls and 301 CE stroke patients, among whom 197 (65.4%) presented with high risk sources of embolism (CE stroke related to AF) and 104 with medium risk sources (CE stroke unrelated to AF). The SNP rs2200733 was analysed using real-time polymorphism chain reaction.

Results

Both univariate and multivariate regression analyses showed that the studied variant affected risk of all CE strokes or CE strokes related to AF in recessive and additive models. The two types of CE stroke differed significantly in demographics and distribution of vascular risk factors.

Conclusions

The SNP rs2200733 on chromosome 4q25 is a risk factor for CE stroke related to AF only.

Get Citation

Keywords

cardioembolic stroke, atrial fibrillation, polymorphism

About this article
Title

The rs2200733 variant on chromosome 4q25 is a risk factor for cardioembolic stroke related to atrial fibrillation in Polish patients

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 45, No 2 (2011)

Pages

148-151

DOI

10.1016/S0028-3843(14)60026-8

Bibliographic record

Neurol Neurochir Pol 2011;45(2):148-151.

Keywords

cardioembolic stroke
atrial fibrillation
polymorphism

Authors

Marcin Wnuk
Joanna Pera
Jeremiasz Jagiełła
Elżbieta Szczygieł
Antoni Ferens
Karolina Spisak
Paweł Wołkow
Maria Kmieć
Jacek Burkot
Joanna Chrzanowska-Waśko
Wojciech Turaj
Agnieszka Słowik

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