Vol 45, No 1 (2011)

open access

Page views 352
Article views/downloads 700
Get Citation

Connect on Social Media

Connect on Social Media

The natural history of Möbius syndrome in a 32-year-old man

Monika Chorąży1, Ryszard Leśniewicz23, Renata Posmyk3, Dorota Halicka1, Aneta Zalewska4, Anna Wincewicz-Pietrzykowska4, Kamil Chorąży5, Wiesław Drozdowski1
DOI: 10.1016/S0028-3843(14)60063-3
Neurol Neurochir Pol 2011;45(1):74-79.


Möbius syndrome (OMIM#157900) is an extremely rare congenital entity involving bilateral or unilateral palsy of the facial nerve, usually with dysfunction of other cranial nerves (second, third, fifth, sixth, ninth, tenth and twelfth). It was estimated that Möbius syndrome occurs in 1 of 50 000 live births. The aetiology and the pathogenesis of the syndrome remain unknown. The majority of published cases were sporadic.

We report on the natural history of a 32-year-old man with de novo Möbius syndrome. The diagnosis was established at the age of 9 months due to partial bilateral facial and abducent nerve palsy. Additionally, the patient demonstrated failure to thrive during infancy and childhood, many dysmorphic features, lower limb anomalies, and hypogonadism in adulthood, but his intelligence was in the normal range. The low quality of life of the patient with Möbius syndrome is emphasized.

Article available in PDF format

View PDF Download PDF file

Neurologia i Neurochirurgia Polska