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Subthalamic deep brain stimulation for the treatment of Parkinson disease
Affiliations- Center of Oncology Maria Sklodowska-Curie Memorial Institute, Warsaw, Poland
- department of neurosurgery
- Clinical Department of Neurology, Voivodeship Hospital in Olsztyn
- 1 Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
- Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University
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Abstract
The role of subthalamic nucleus deep brain stimulation (STN DBS) in the treatment of Parkinson disease (PD) is well established. The authors present a group of patients diagnosed with PD who were treated with STN DBS.
Material and methodsBetween 2008 and 2009, 32 female and 34 male patients with PD were treated with STN DBS. Mean age at implantation was 57 ± 12 years. PD lasted from 6 to 21 years (mean 10 years). Patients were qualified for the surgery according to the CAPSIT-PD criteria. The STN was identified with direct and indirect methods. Macrostimulation and microrecording for STN identification were used in all cases. A unilateral STN DBS system was implanted in two cases and bilateral implantation was performed among rest of the group. Outcome was assessed six months after implantation.
ResultsThe mean reduction of UPDRS III score among 51 patients who underwent follow-up was 45% (5-89%). Reduction of levodopa consumption varied from 15 to 100%. Infection forced the authors to remove the DBS system in one case four months after implantation. Skin erosion above the internal pulse generator was noted in four cases.
ConclusionsCardinal symptoms of Parkinson's disease can be safely and effectively treated with STN DBS in selected group of patients.
Abstract
The role of subthalamic nucleus deep brain stimulation (STN DBS) in the treatment of Parkinson disease (PD) is well established. The authors present a group of patients diagnosed with PD who were treated with STN DBS.
Material and methodsBetween 2008 and 2009, 32 female and 34 male patients with PD were treated with STN DBS. Mean age at implantation was 57 ± 12 years. PD lasted from 6 to 21 years (mean 10 years). Patients were qualified for the surgery according to the CAPSIT-PD criteria. The STN was identified with direct and indirect methods. Macrostimulation and microrecording for STN identification were used in all cases. A unilateral STN DBS system was implanted in two cases and bilateral implantation was performed among rest of the group. Outcome was assessed six months after implantation.
ResultsThe mean reduction of UPDRS III score among 51 patients who underwent follow-up was 45% (5-89%). Reduction of levodopa consumption varied from 15 to 100%. Infection forced the authors to remove the DBS system in one case four months after implantation. Skin erosion above the internal pulse generator was noted in four cases.
ConclusionsCardinal symptoms of Parkinson's disease can be safely and effectively treated with STN DBS in selected group of patients.
Keywords
Parkinson disease, deep brain stimulation, subthalamic nucleus
About this articleTitle
Subthalamic deep brain stimulation for the treatment of Parkinson disease
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
32-36
Page views
518
Article views/downloads
642
DOI
10.1016/S0028-3843(14)60057-8
Bibliographic record
Neurol Neurochir Pol 2011;45(1):32-36.
Keywords
Parkinson disease
deep brain stimulation
subthalamic nucleus
Authors
Tomasz Mandat
Tomasz Tykocki
Henryk Koziara
Dariusz Koziorowski
Bogdan Brodacki
Rafał Rola
Wiesław Bonicki
Pawel Nauman
