open access

Vol 45, No 1 (2011)
ARTYKUŁ ORYGINALNY
Submitted: 2010-06-22
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Cerebral abnormalities in infants with myelomeningocele

George A. Alexiou, Maria K. Zarifi, George Georgoulis, Eleni Mpouza, Christiana Prodromou, Athina Moutafi, Marina Anagnostakou, George Sfakianos, Neofytos Prodromou
DOI: 10.1016/S0028-3843(14)60055-4
·
Neurol Neurochir Pol 2011;45(1):18-23.

open access

Vol 45, No 1 (2011)
ARTYKUŁ ORYGINALNY
Submitted: 2010-06-22

Abstract

Background and purpose

We evaluated brain abnormalities associated with myelomeningocele in infants.

Material and methods

Between June 1995 and June 2008, 42 patients with myelomeningocele were treated in our hospital. Only 24 patients (13 males, 11 females, mean age 1.5 months, range 1 day – 11 months) were evaluated by both spinal and brain magnetic resonance imaging (MRI) and were enrolled in the study.

Results

Brain MRI revealed: hydrocephalus in 21 (87.5%) patients, all of whom required immediate shunting. Total agenesis of the corpus callosum was observed in 2 (8.3%) patients, partial agenesis was seen in 4 (17%) patients and 8 (34%) patients had dysplasia of the corpus callosum. Absence of the septum pellucidum was observed in 2 (8%) patients. Widening of the interhemispheric fissure and colpocephaly were noted in 10 (41%) and in 3 (12%) patients, respectively. Abnormal white matter maturation was observed in 2 (8%) patients. Small posterior fossa was observed in 18 (74%) patients, Chiari malformation in 16 (67%) patients, cerebellar and brain stem hypoplasia in 3 (12%) and 7 (30%) patients, respectively.

Conclusions

MRI examination of the myelomeningocele site is not sufficient. Clinicians should consider obtaining imaging studies of the entire neuraxis in patients with myelomeningocele.

Abstract

Background and purpose

We evaluated brain abnormalities associated with myelomeningocele in infants.

Material and methods

Between June 1995 and June 2008, 42 patients with myelomeningocele were treated in our hospital. Only 24 patients (13 males, 11 females, mean age 1.5 months, range 1 day – 11 months) were evaluated by both spinal and brain magnetic resonance imaging (MRI) and were enrolled in the study.

Results

Brain MRI revealed: hydrocephalus in 21 (87.5%) patients, all of whom required immediate shunting. Total agenesis of the corpus callosum was observed in 2 (8.3%) patients, partial agenesis was seen in 4 (17%) patients and 8 (34%) patients had dysplasia of the corpus callosum. Absence of the septum pellucidum was observed in 2 (8%) patients. Widening of the interhemispheric fissure and colpocephaly were noted in 10 (41%) and in 3 (12%) patients, respectively. Abnormal white matter maturation was observed in 2 (8%) patients. Small posterior fossa was observed in 18 (74%) patients, Chiari malformation in 16 (67%) patients, cerebellar and brain stem hypoplasia in 3 (12%) and 7 (30%) patients, respectively.

Conclusions

MRI examination of the myelomeningocele site is not sufficient. Clinicians should consider obtaining imaging studies of the entire neuraxis in patients with myelomeningocele.

Get Citation

Keywords

spinal dysraphism, myelomeningocele, MRI, brain

About this article
Title

Cerebral abnormalities in infants with myelomeningocele

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 45, No 1 (2011)

Pages

18-23

DOI

10.1016/S0028-3843(14)60055-4

Bibliographic record

Neurol Neurochir Pol 2011;45(1):18-23.

Keywords

spinal dysraphism
myelomeningocele
MRI
brain

Authors

George A. Alexiou
Maria K. Zarifi
George Georgoulis
Eleni Mpouza
Christiana Prodromou
Athina Moutafi
Marina Anagnostakou
George Sfakianos
Neofytos Prodromou

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